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N,N,N',N'-Tetramethyl-4,4'-methylenedianiline

CAS 101-61-1 · 100/100 · High conf.

Also registered as 2 other CAS numbers

137198-51-7 · 30135-64-9

N,N,N',N'-Tetramethyl-4,4'-methylenedianiline chemical structure

Concern score

100/100Critical concern driven by cmr.
High confidence

N,N,N',N'-Tetramethyl-4,4'-methylenedianiline in plain language

What it is

Also known as Michler's base · 4,4'-Methylenebis(N,N-dimethylaniline) · Bis(p-(dimethylamino)phenyl)methane · 4,4'-(DIMETHYLAMINO)DIPHENYLMETHANE · 4,4'-BIS(DIMETHYLAMINO)DIPHENYLMETHANE · 4,4'-BIS(DIMETHYLAMINOPHENYL)METHANE

Show all 30 names

4,4'-METHYLENEBIS(N,N-DIMETHYL)BENZENAMINE · 4,4'-TETRAMETHYLDIAMINODIPHENYLMETHANE · Arnold's base · Michler's hydride · Michler's methane · N,N,N',N'-TETRAMETHYL-4,4'-DIAMINODIPHENYLMETHANE · N,N,N',N-TETRAMETHYL-4,4'-METHYLENEDIANILINE · P,p'-bis(dimethylamino)diphenylmethane · Reduced michler's ketone · Tetrabase · 4,4'-METHYLENEBIS(N,N-DIMETHYLBENZENAMINE) · 4,4'-Methylene bis(N,N-dimethyl) benzenamine · Aniline, 4,4'-METHYLENEBIS(N,N-DIMETHYL- · BIS(4-(N,N-DIMETHYLAMINO)PHENYL)METHANE · Baze michlerova · Bis(p-dimethylamino)diphenylmethane · Bis(p-dimethylaminophenyl)methane · Diphenylmethane, tetramethyldiamino- · Methane base · Methylene base · NCI-C01990 · Tetramethyldiaminodiphenylmethane · p,p'-Bis(N,N-dimethylaminophenyl)methane · p,p-Dimethylaminodiphenylmethane

What it does

We don't have a plain-language description for N,N,N',N'-Tetramethyl-4,4'-methylenedianiline yet.

Is it a concern?
Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.

Why it's flagged

  • Cmr

N,N,N',N'-Tetramethyl-4,4'-methylenedianiline is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Carcinogenic Cat. 1B()

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 1161.
    • Cosmetics Regulation annex II / ref 1161.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 10 composition records across product categories including Laboratory supplies, Industrial products.
    • EPA CPDat observed this chemical in 10 composition records across product categories including Laboratory supplies, Industrial products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for N,N,N',N'-Tetramethyl-4,4'-methylenedianiline. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for N,N,N',N'-Tetramethyl-4,4'-methylenedianiline yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-15

    Open →
  • EPA Chemical and Products Database

    exposure · updated March 8, 2019

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed N,N,N',N'-Tetramethyl-4,4'-methylenedianiline in a product composition. These are source records, not Greenveil catalog products.

Source records

10

Named organisations

3

Laboratory suppliesIndustrial products
See products using N,N,N',N'-Tetramethyl-4,4'-methylenedianiline →