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Toluene

CAS 25013-04-1 · 70/100 · High conf.

Also registered as 3 other CAS numbers

1053657-77-4 · 1202864-97-8 · 108-88-3

Toluene chemical structure

Concern score

70/100High concern driven by cmr.
High confidence

Toluene in plain language

What it is

Also known as Antisal 1A · Methacide · 1-Methylbenzene · Benzene, methyl- · Caswell No. 859 · Methyl benzene

Show all 26 names

Methane, phenyl- · Methylbenzene · Methylbenzol · NCI-C07272 · Phenylmethane · RCRA waste number U220 · Toluol · Tolueen · Toluen · Tolueno · Toluolo · Toulene · monomethyl benzene · phenyl methane · tolu-sol · toluene (sara 313) (cercla)(vp = 22 @ 68f) · toluene (sara 313) (vp: 22 mmgh @ 68f) · toluene (sara iii) · toluene (sara iii) (cercla) (vapor pressure 22 mm hg @ 68f) · toluene (sara iii) (vapor pressure 22 mm hg @ 68f)

What it does

Used in cosmetics as an antioxidant and a solvent.

  • Antioxidant
  • Solvent
  • Cleaning agent
Is it a concern?
High concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is restricted in EU cosmetics.

Why it's flagged

  • Cmr

Toluene is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Cleaning
  • Industrial
  • EUEC

    Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: Nail products Maximum concentration: 25% Conditions of use and warnings: Keep out of reach of children. To be used by adults only CMR: Reprotoxic Cat. 2()

    restricted
    View source →
  • EUCosIngActive2 entries
  • USEPAcommercial use observedEPA CPDat observed this chemical in 21085 composition records across product categories including Furniture and furnishings, Raw materials, Construction and building materials. EPA CPDat classifies this chemical for functional uses including Solvent, Antioxidant, Propellants, non-motive (blowing agents).
    • EPA CPDat observed this chemical in 21085 composition records across product categories including Furniture and furnishings, Raw materials, Construction and building materials. EPA CPDat classifies this chemical for functional uses including Solvent, Antioxidant, Propellants, non-motive (blowing agents).Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 3 active drug products and 5 total products.
    • FDA NDC lists this ingredient in 3 active drug products and 5 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Toluene. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Toluene yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2013-05-24

    Open →
  • EPA Chemical and Products Database

    exposure · updated october 24, 2019

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2028-05-17

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

alfa-chemistry.com

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Toluene in a product composition. These are source records, not Greenveil catalog products.

Source records

21,085

Named organisations

6

Furniture and furnishingsRaw materialsConstruction and building materialsHome maintenanceCleaning products and household careConstruction

Typical roles

AntioxidantSolventCleaning agent
See products using Toluene →