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Methoxydiglycol

CAS 111-77-3 · 100/100 · High conf.

Also registered as 1 other CAS number

1552323-12-2

Methoxydiglycol chemical structure

Concern score

100/100Critical concern driven by cmr.
High confidence

Methoxydiglycol in plain language

What it is

Also known as Diethylene glycol monomethyl ether · 2-(2-Methoxyethoxy)ethan-1-ol · 2-(2-methoxyethoxy)ethanol · Mecb · 2-(2-METHOXY-ETHOXY)ETHANOL · 2-(2-metoxietoxi)etanol

Show all 27 names

2-Hydroxyethyl 2-methoxyethyl ether · 3,6-Dioxa-1-heptanol · Degme · Dowanol dm · Diethylene glycol methyl ether · Diethyleneglycol monomethyl ether · Diglycol monomethyl ether · Dowanol 16 · Ektasolve dm · Ethanol, 2,2'-oxybis-, monomethyl ether · Ethanol, 2-(2-methoxyethoxy)- 2-(2-Methoxyethoxy)ethan-1-ol · Ethylene diglycol monomethyl ether · Jeffersol DM · Methyl digol · Methyl dioxitol · Methyl karbitol · Poly-solv dm · beta-Methoxy-beta'-hydroxydiethyl ether · di(ethylene glycol) methyl ether (dowanol dm) · diethylene glycol ethylether · methyl carbitol

What it does

Used in cosmetics as a solvent, a thickener and a fragrance ingredient.

  • Solvent
  • Viscosity controlling
  • Perfuming
  • Fragrance
  • Thickener
  • Film former
Is it a concern?
Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.

Why it's flagged

  • Cmr

2-Methoxyethoxy)ethanol (Diethylene glycol mono­methyl ether; DEGME) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Cleaning
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Reprotoxic Cat. 1B()

    banned
    View source →
  • EUCosIngActive2 entries
  • USEPAcommercial use observedEPA CPDat observed this chemical in 841 composition records across product categories including Specialty occupational products, Raw materials, Cleaning and safety. EPA CPDat classifies this chemical for functional uses including Solvent, Deodorizer, Fragrance.
    • EPA CPDat observed this chemical in 841 composition records across product categories including Specialty occupational products, Raw materials, Cleaning and safety. EPA CPDat classifies this chemical for functional uses including Solvent, Deodorizer, Fragrance.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Methoxydiglycol. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Methoxydiglycol yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2021-05-17

    Open →
  • EPA Chemical and Products Database

    exposure · updated april 11, 2017

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (2)
Openfda substance

webbook.nist.gov

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Methoxydiglycol in a product composition. These are source records, not Greenveil catalog products.

Source records

841

Named organisations

6

Specialty occupational productsRaw materialsCleaning and safetyIndustrial productsHome maintenanceVehicle

Typical roles

SolventViscosity controllingPerfumingFragranceThickenerFilm former
See products using Methoxydiglycol →