- beauty
- cleaning
- industrial
Methoxydiglycol
CAS 111-77-3 · 100/100 · High conf.
Also registered as 1 other CAS number
1552323-12-2
Concern score
Methoxydiglycol in plain language
Also known as Diethylene glycol monomethyl ether · 2-(2-Methoxyethoxy)ethan-1-ol · 2-(2-methoxyethoxy)ethanol · Mecb · 2-(2-METHOXY-ETHOXY)ETHANOL · 2-(2-metoxietoxi)etanol
Show all 27 names
2-Hydroxyethyl 2-methoxyethyl ether · 3,6-Dioxa-1-heptanol · Degme · Dowanol dm · Diethylene glycol methyl ether · Diethyleneglycol monomethyl ether · Diglycol monomethyl ether · Dowanol 16 · Ektasolve dm · Ethanol, 2,2'-oxybis-, monomethyl ether · Ethanol, 2-(2-methoxyethoxy)- 2-(2-Methoxyethoxy)ethan-1-ol · Ethylene diglycol monomethyl ether · Jeffersol DM · Methyl digol · Methyl dioxitol · Methyl karbitol · Poly-solv dm · beta-Methoxy-beta'-hydroxydiethyl ether · di(ethylene glycol) methyl ether (dowanol dm) · diethylene glycol ethylether · methyl carbitol
Used in cosmetics as a solvent, a thickener and a fragrance ingredient.
- Solvent
- Viscosity controlling
- Perfuming
- Fragrance
- Thickener
- Film former
- Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.
Why it's flagged
- Cmr
2-Methoxyethoxy)ethanol (Diethylene glycol monomethyl ether; DEGME) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.
RestrictedEU EC — banned
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
Restrictions first, then routine listings from published regulatory sources.
- EU Annex II — prohibited
- EU prohibited in cosmetics
- Found in consumer products
- Cleaning
- Industrial
- View source →banned
EUEC
Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Reprotoxic Cat. 1B()
USEPAcommercial use observedEPA CPDat observed this chemical in 841 composition records across product categories including Specialty occupational products, Raw materials, Cleaning and safety. EPA CPDat classifies this chemical for functional uses including Solvent, Deodorizer, Fragrance.
- EPA CPDat observed this chemical in 841 composition records across product categories including Specialty occupational products, Raw materials, Cleaning and safety. EPA CPDat classifies this chemical for functional uses including Solvent, Deodorizer, Fragrance.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
No expert opinion on file for Methoxydiglycol. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for Methoxydiglycol yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2021-05-17
- Open →
EPA Chemical and Products Database
exposure · updated april 11, 2017
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Reference links (2)
chemblink.com
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
Not a strong fit for fragrance avoidance because it carries Fragrance.
The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.
Where it has been recorded
How often EPA CPDat has listed Methoxydiglycol in a product composition. These are source records, not Greenveil catalog products.
Source records
841
Named organisations
6
Typical roles