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Chlorophene

CAS 8013-49-8 · 100/100 · High conf.

Also registered as 2 other CAS numbers

144246-47-9 · 120-32-1

Chlorophene chemical structure

Concern score

100/100Critical concern driven by cmr.
High confidence

Chlorophene in plain language

What it is

Also known as Clorophene · Clorofene · Clorofene; chlorophene; 2-benzyl-4-chlorophenol · 2-Benzyl-4-chlorophenol · 4-Chloro-α-phenyl-O-cresol · 5-CHLORO-2-HYDROXYDIPHENYLMETHANE

Show all 33 names

O-benzyl-p-chlorophenol · #0-benzyl-p-chlorophenate · 2-BENZYL-4-CHLOR-PHENOL · 2-Hydroxy-5-chlorodiphenylmethane · 4-CHLORO-.ALPHA.-PHENYL-O-CRESOL · 4-CHLORO-2-BENZYLPHENOL · 4-Chloro-2-(phenylmethyl)phenol · Benzyl chloro phenol · Benzylchlorophenol · Clorofeno · Clorofenum · Ketolin-H · Neosabenyl · Orthobenzyl-p-chlorophenol · Orthobenzylparachlorophenol · Phenol, 4-chloro-2-(phenylmethyl)- · Santophen 1 · Santophen 1 flake · Santophen I · Santophen I germicide · Septiphene · o-Cresol, 4-chloro-α-phenyl- · o-benzyl-o-chlorophenol · o-benzyl-p-chlorophenol ortho-benzyl-para-chlorophenol · ochlorophenol · ortho-benzyl para chlorophenol · sodium o-benzyl-p-chlorophenate

What it does

Used in cosmetics as a preservative and an antimicrobial. Chlorophene is the halogenated phenolic compound.

  • Preservative
  • Antimicrobial
Is it a concern?
Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.

Why it's flagged

  • Cmr

Clorofene; chlorophene; 2-benzyl-4-chlorophenol is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Carcinogenic Cat. 2(),Reprotoxic Cat. 2()

    banned
    View source →
  • EUCosIngActive2 entries
    • Chlorophene is the halogenated phenolic compound that conforms to the formula: Restriction: II/1602Source →
    • Cosmetics Regulation annex II / ref 1602.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 90 composition records across product categories including Cleaning and safety, Cleaning products and household care, Personal care. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative, Active ingredient.
    • EPA CPDat observed this chemical in 90 composition records across product categories including Cleaning and safety, Cleaning products and household care, Personal care. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative, Active ingredient.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Chlorophene. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Chlorophene yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2020-07-30

    Open →
  • EPA Chemical and Products Database

    exposure · updated october 15, 2019

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (2)
Openfda substance

ncbi.nlm.nih.gov

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Chlorophene in a product composition. These are source records, not Greenveil catalog products.

Source records

90

Named organisations

6

Cleaning and safetyCleaning products and household carePersonal careArts and crafts/office suppliesMedical/dentalRaw materials

Typical roles

PreservativeAntimicrobial
See products using Chlorophene →