# Ammonium fluoride

URL: https://app.greenveil.ai/ingredients/ingredient_cas_12125_01_8
Categories: beauty, cleaning, food, industrial, pharma
Functions: Antiplaque, Oral care
Identifier: DTXSID6050463

> Ammonium fluoride: Used in cosmetics as an antiplaque and an oral-care ingredient. Greenveil chemical-concern score: 70/100 — High concern based on regulatory listings.. Compiled from 7 published data sources.

## Safety assessment

- Chemical concern score: 70/100 — High concern based on regulatory listings.
- Confidence in this assessment: High
- Is it a concern? High concern: no hazard classifications on record. It is restricted in EU cosmetics.
- Rationale: Ammonium fluoride is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: Active — Restriction: III/33
- EU: Active — Cosmetics Regulation annex III / ref 33.
- EU: restricted — Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: Oral products Maximum concentration: 0,15 % calculated as F. When mixed with other fluorine compounds permitted under this Annex, total F concentration must not exceed 0,15 % Conditions of use and warnings: Contains ammonium fluoride. For any toothpaste with compounds containing fluorine in a concentration of 0,1 to 0,15 % calculated as F unless it is already labelled as contra-indicated for children (e.g. “for adult use only”) the following labelling is obligatory: “Children of 6 years and younger: use a pea-sized amount for supervised brushing to minimise swallowing. In case of intake of…
- US: commercial use observed — EPA CPDat observed this chemical in 57 composition records across product categories including Laboratory supplies, Personal care, Food and drug. EPA CPDat classifies this chemical for functional uses including oral care, Pharmaceutical.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/31865
- EU CosIng Cosmetics Regulation Annexes (updated 2013-05-14): https://ec.europa.eu/growth/tools-databases/cosing/reference/annexes/list/III
- EPA Chemical and Products Database (updated 2020-04-22): http://siri.org/msds/f2/bmw/bmwcb.html
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:4QT928IM0A
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/25516

_Assessed by Greenveil._