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  • beauty
  • cleaning
  • industrial

1,4-Dioxane

CAS 123-91-1 · 100/100 · High conf.

Also registered as 5 other CAS numbers

28552-22-9 · 28347-88-8 · 28347-91-3 · 39449-24-6 · 54841-74-6

1,4-Dioxane chemical structure

Concern score

100/100Critical concern driven by cmr.
High confidence

1,4-Dioxane in plain language

What it is

Also known as Dioxan · Dioxane · 1,4-Diethylene dioxide · 1,4-Diethyleneoxide · 1,4-Dioxacyclohexane · 1,4-Dioxan

Show all 24 names

1,4-Dioxin, tetrahydro- · 1,4-dioxanne · 1,4-dioxano · Di(ethylene oxide) · Diethylene dioxide · Diokan · Dioksan · Dioxan-1,4 · Dioxane-1,4 · Dioxanne · Dioxyethylene ether · Glycol ethylene ether · Tetrahydro-1,4-dioxin · Tetrahydro-p-dioxin · Tetrahydro-para-dioxin · diethylene ether · p-Dioxan · p-Dioxane

What it does

Used in consumer products as a surfactant and a fragrance ingredient.

  • Surfactant
  • Fragrance
Is it a concern?
Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.

Why it's flagged

  • Cmr

Dioxane is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Cleaning
  • Industrial

  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Carcinogenic Cat. 2()

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 343.
    • Cosmetics Regulation annex II / ref 343.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 460 composition records across product categories including Industrial products, Specialty occupational products, Raw materials. EPA CPDat classifies this chemical for functional uses including No specific technical function, Surfactant (surface active agent), Trace byproduct.
    • EPA CPDat observed this chemical in 460 composition records across product categories including Industrial products, Specialty occupational products, Raw materials. EPA CPDat classifies this chemical for functional uses including No specific technical function, Surfactant (surface active agent), Trace byproduct.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for 1,4-Dioxane. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for 1,4-Dioxane yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-15

    Open →

  • EPA Chemical and Products Database

    exposure · updated september 30, 2011

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed 1,4-Dioxane in a product composition. These are source records, not Greenveil catalog products.

Source records

460

Named organisations

6

Industrial productsSpecialty occupational productsRaw materialsVehicleLaboratory suppliesCleaning and safety

Typical roles

SurfactantFragrance
See products using 1,4-Dioxane →