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Tetrachloroethylene

CAS 127-18-4 · 100/100 · High conf.

Also registered as 1 other CAS number

25135-99-3

Tetrachloroethylene chemical structure

Concern score

100/100Critical concern driven by cmr.
High confidence

Tetrachloroethylene in plain language

What it is

Also known as Tetrachlorethylene · Tetrachloroethylene (perchloroethylene) · 1,1,2,2-tetrachloroethene · Tetrachloroethene · 1,1,2,2-TETRACHLOROETHYLENE · Ankilostin

Show all 27 names

Asahi Perchlor · Didakene · Ethene, 1,​1,​2,​2-​tetrachloro- · Ethene, tetrachloro- · Ethylene tetrachloride · Perc · Perawin · Perchlorethylene · Perclene · Tetlen · Tetracap · Tetrachloraethen · Tetraguer · Tetraleno · Tetralex · Tetropil · perchloroethylene · perchloroethylene (tetrachloroethylene) (sara iii) · perchloroethylene (tetrachloroethylene) (sara 313) (cercla) · perchloroethylene (tetrachloroethylene) (suspected animal · tetrachloroethylene (sara 313) (cercla)

What it does

Used in consumer products as a solvent.

  • Solvent
Is it a concern?
Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.

Why it's flagged

  • Cmr

Tetrachloroethylene is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Cleaning
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Carcinogenic Cat. 2()

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 314.
    • Cosmetics Regulation annex II / ref 314.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 845 composition records across product categories including Raw materials, Specialty occupational products, Cleaning and safety. EPA CPDat classifies this chemical for functional uses including Solvent, Solubility enhancer.
    • EPA CPDat observed this chemical in 845 composition records across product categories including Raw materials, Specialty occupational products, Cleaning and safety. EPA CPDat classifies this chemical for functional uses including Solvent, Solubility enhancer.Source →
  • USFDAinactive ingredient databaseRoute: ORAL; Dosage form: TABLET, DELAYED RELEASE; Potency: 702 mg
    • Route: ORAL; Dosage form: TABLET, DELAYED RELEASE; Potency: 702 mgSource →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Tetrachloroethylene. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Tetrachloroethylene yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-15

    Open →
  • EPA Chemical and Products Database

    exposure · updated october 14, 2019

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Tetrachloroethylene in a product composition. These are source records, not Greenveil catalog products.

Source records

845

Named organisations

6

Raw materialsSpecialty occupational productsCleaning and safetyHome maintenanceVehicleLaboratory supplies

Typical roles

Solvent
See products using Tetrachloroethylene →