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N,N-Dimethylacetamide

CAS 127-19-5 · 100/100 · High conf.

N,N-Dimethylacetamide chemical structure

Concern score

100/100Critical concern driven by cmr.
High confidence

N,N-Dimethylacetamide in plain language

What it is

Also known as Dimethylacetamide · Dimethylamide acetic acid · Acetamide, N,N-dimethyl- · Acetdimethylamide · Acetic acid dimethylamide · Acetyldimethylamine

Show all 20 names

Cbc 510337 · DMAc · Dimethylacetone amide · Dimethylamid kyseliny octove · Dimethylamide acetate · Essigsaeure-dimethylamid · N,n-dimethyl acetamide · N,N-Dimethylacetamid · N,N-Dimethylethanamide · Sk 7176 · U-5954 · dimethyl acetamide · dimethyl acetamide (residual in film) · dimethyl acetamide vp = 2.0

What it does

Used in consumer products as a solvent.

  • Solvent
Is it a concern?
Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.

Why it's flagged

  • Cmr

N,N-Dimethylacetamide is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Pharma
  • Food
  • Industrial

  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Reprotoxic Cat. 1B(C=>5%)

    banned
    View source →
  • USFDAinactive ingredient database3 entries — 2 administration routes
    • Route: INTRAVENOUS; Dosage form: INJECTION; Maximum daily exposure: 11583 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 9891 mgSource →
    • Route: NASAL; Dosage form: SPRAY; Potency: 0.01 mlSource →
  • EUCosIngActiveCosmetics Regulation annex II / ref 747.
    • Cosmetics Regulation annex II / ref 747.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 210 composition records across product categories including Specialty occupational products, Laboratory supplies, Raw materials. EPA CPDat classifies this chemical for functional uses including Processing aids not otherwise specified, Solvent.
    • EPA CPDat observed this chemical in 210 composition records across product categories including Specialty occupational products, Laboratory supplies, Raw materials. EPA CPDat classifies this chemical for functional uses including Processing aids not otherwise specified, Solvent.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for N,N-Dimethylacetamide. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    No EFSA opinion on file.

Evidence & sources

No graded research studies for N,N-Dimethylacetamide yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-15

    Open →

  • EPA Chemical and Products Database

    exposure · updated april 19, 2018

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed N,N-Dimethylacetamide in a product composition. These are source records, not Greenveil catalog products.

Source records

210

Named organisations

6

Specialty occupational productsLaboratory suppliesRaw materialsLandscape/yardFood and drug

Typical roles

Solvent
See products using N,N-Dimethylacetamide →