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Hydroxyapatite

CAS 1306-06-5 · 70/100 · High conf.

Concern score

70/100High concern based on regulatory listings.
High confidence

Hydroxyapatite in plain language

What it is

On cosmetic ingredient lists it appears as “Calcium hydroxyapatite”.

Also known as Calcium hydroxyapatite · Hydroxyapatite (nano) · Hydroxylapatite (Ca5(OH)(PO4)3) · Durapatite (USAN) · Hydroxylapatite · calcium phosphate

Show all 8 names

calcium phosphate tribasic/tri-calcium phosphate · durapatite

What it does

Used in cosmetics as a skin-conditioning agent, an abrasive and an oral-care ingredient. Calcium Hydroxyapatite is the mineral.

  • Skin conditioning
  • Abrasive
  • Oral care
  • Bulking
  • Conditioner
Is it a concern?
High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

Hydroxyapatite is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Cleaning
  • Industrial

  • EUEC

    Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: (a) Toothpaste (b) Mouthwash Maximum concentration: (a) 10 % (b) 0,465 % Other conditions: For (a) and (b): Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation. Only nanomaterials having the following characteristics are allowed: — [composed of] rod-shaped particles of which at least 95,8 % (in particle number) have an aspect ratio less than 3, and the remaining 4,2 % have an aspect ratio not exceeding 4,9; — the particles are not coated…

    restricted
    View source →
  • EUCosIngActive3 entries
    • Calcium Hydroxyapatite is the mineralSource →
    • Hydroxyapatite is a mineral obtained from pearl oyster shells, salmon bones, phosphate rock, or derived synthetically. It conforms generally to the formulaSource →
    • Cosmetics Regulation annex III / ref 372.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 8 composition records across product categories including Laboratory supplies, Raw materials, Cleaning and safety. EPA CPDat classifies this chemical for functional uses including Abrasive, Softener and conditioner, oral care.
    • EPA CPDat observed this chemical in 8 composition records across product categories including Laboratory supplies, Raw materials, Cleaning and safety. EPA CPDat classifies this chemical for functional uses including Abrasive, Softener and conditioner, oral care.Source →

Expert safety opinions

No expert opinion on file for Hydroxyapatite. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Hydroxyapatite yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

3 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2024-06-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2019-12-20

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Hydroxyapatite in a product composition. These are source records, not Greenveil catalog products.

Source records

8

Named organisations

2

Laboratory suppliesRaw materialsCleaning and safety

Typical roles

Skin conditioningAbrasiveOral careBulkingConditioner
See products using Hydroxyapatite →

Catalog

Found in these products

Their ingredient lists include Hydroxyapatite; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 68 →Find products without it →