beauty
food
pharma

Quinine

CAS 130-95-0 · 70/100 · High conf.

Also registered as 36 other CAS numbers

72402-53-0 · 6912-57-8 · 12239-42-8 · 21480-31-9 · 55980-20-6 · 72646-90-3 · 95650-40-1 · 128544-03-6 · 767303-40-2 · 840482-04-4 · 857212-53-4 · 864908-93-0 · 875538-34-4 · 888714-03-2 · 890027-24-4 · 894767-09-0 · 898813-59-7 · 898814-28-3 · 899813-83-3 · 900786-66-5 · 900789-95-9 · 906550-97-8 · 909263-47-4 · 909767-48-2 · 909882-78-6 · 910878-25-0 · 910880-97-6 · 911445-75-5 · 918778-04-8 · 1071756-51-8 · 1267651-57-9 · 1628705-47-4 · 2244812-93-7 · 2244812-97-1 · 2409557-51-1 · 2566761-34-8

Concern score

70/100High concern based on regulatory listings.

High confidence

Quinine in plain language

What it is: Also known as Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)- its salts · (8S,9R)-6'-METHOXYCINCHONAN-9-OL · (9R)-6'-Methoxy-8alpha-cinchonan-9-ol · Qualaquin · Rezquin · (8-alpha,9R)-6'-Methoxycinchonan-9-ol
Show all 20 names
(8S,9R)-Quinine · (8α,9R)-6'-Methoxycinchonan-9-ol · (R)-(-)-Quinine · (R)-(-)-Quinine, 6-methoxycinchonidine · 6'-Methoxycinchonidine · 6-Methoxycinchonine · Chinin · Chinine · Cinchonan-9-ol, 6'-methoxy-, (8.alpha., 9R)- · Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)- · WR297608 · chininum · quinina · Chininum purum
What it does: Used in cosmetics as a hair conditioner, a fragrance ingredient and a denaturant. Quinine is an alkaloid from the bark of Cinchona officinalis.
Hair conditioning
Fragrance
Denaturant
Conditioner
Deodorant
Is it a concern?: High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)- its salts is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

In marketed US drugs
EU Annex III — restricted
EU restricted in cosmetics

Recorded in these product areas

Found in consumer products
Beauty

EUEC
Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: (a) Hair rinse-off products (b) Hair leave-on products Maximum concentration: (a) 0.5% (as quinine base) (b) 0.2% (as quinine base)
restricted
View source →

EUCosIngActive2 entries
- Cosmetics Regulation annex III / ref 21.Source →
- Quinine is an alkaloid from the bark of Cinchona officinalis. It conforms to the formula Restriction: III/21Source →
EUEFSAEvaluatedEFSA OpenFoodTox substance characterisation is available. Molecular formula: C20H24N2O2.
- EFSA OpenFoodTox substance characterisation is available. Molecular formula: C20H24N2O2.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 1 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Deodorizer, Softener and conditioner, Pharmaceutical.
- EPA CPDat observed this chemical in 1 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Deodorizer, Softener and conditioner, Pharmaceutical.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 1 active drug products and 1 total products.
- FDA NDC lists this ingredient in 1 active drug products and 1 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
USUSDA FoodData Centralobserved in branded food ingredient statementsObserved in 2 USDA branded foods including 1 LITER BOTTLE TONIC WATER, 1 LITER BOTTLE TONIC WATER WITH LIME.
- Observed in 2 USDA branded foods including 1 LITER BOTTLE TONIC WATER, 1 LITER BOTTLE TONIC WATER WITH LIME.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- EFSA OpenFoodTox substance characterisation is available. Molecular formula: C20H24N2O2.
  2023 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Quinine yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

10 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2010-10-17
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated November 2007
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA National Drug Code Directory
regulatory · updated 2026-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →
USDA Branded Foods
product_occurrence · updated 2026-02-19
Open →

Reference links (1)

Openfda substance

clinicalkey.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often USDA FoodData Central has listed Quinine in a product composition. These are source records, not Greenveil catalog products.

Source records

Named organisations

Non Alcoholic Beverages - Ready to Drink

Typical roles

Hair conditioningFragranceDenaturantConditionerDeodorant

See products using Quinine →

Catalog

Found in these products

Their ingredient lists include Quinine; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 207 →Find products without it →