Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
CAS 1449653-83-1 · 70/100 · High conf.
Concern score
Also known as Q27286603 · UNII-PKS7O14JK4
Used in cosmetics as a hair dye. HC Orange No. 6 is the hair color.
Di-[2-[(E)-2-[4-[bis(2-hydroxyethyl)aminophenyl]vinyl]pyridin-1-ium]-ethyl]disulphide dimethanesulfonate is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.
RestrictedEU EC — restricted
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Restrictions first, then routine listings from published regulatory sources.
EUEC
Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: Hair dye substance in non-oxidative hair dye products Maximum concentration: As from 3 June 2021: 0,5 % Other conditions: Methanesulfonates impurities, in particular ethyl methanesulfonate shall not be present.
No expert opinion on file for Hc orange no. 6. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
No graded research studies for Hc orange no. 6 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
CosIng
regulatory · updated 2026-09-23
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2020-11-24
EPA Chemical and Products Database
exposure · updated 2019-12-20
FDA GSRS UNII
registry · updated 2026-02-26
openFDA Substance
registry · updated 2026-05-24
PubChem Live Enrichment
chemistry · updated 2026-05-17
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.