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4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF

CAS 1478-61-1 · 100/100 · High conf.

Also registered as 2 other CAS numbers

110444-90-1 · 1429425-28-4

4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF in plain language

What it is

Also known as Bisphenol AF · 2,2-BIS(4'-HYDROXYPHENYL)HEXAFLUOROPROPANE · 4,4'-(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)diphenol · 1,1,1,3,3,3-HEXAFLUORO-2,2-BIS(4-HYDROXYPHENYL)PROPANE · 2,2-BIS(4-HYDROXYPHENYL)HEXAFLUOROPROPANE · 2,2-Bis(4-hydroxyphenyl)perfluoropropane

Show all 17 names

2,2-Bis-(p-hydroxyphenyl)-hexafluoropropane · 4,4'- (hexaf luoroisopropylidene)diphenol · 4,4'- (hexafluoroisopropylidene)diphenol · 4,4'-(Trifluoro-1-(trifluoromethyl)ethylidene)diphenol · BPAF compound · Biphenol AF · Curative 30 · Hexafluoroacetone bisphenol A · Hexafluorodiphenylolpropane · Hexafluoroisopropylidenebis(4-hydroxybenzene) · hexafluorobisphenol a

What it does

We don't have a plain-language description for 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF yet.

Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Pharma
  • Food
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 1743.
    • Cosmetics Regulation annex II / ref 1743.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 25 composition records across product categories including Food and drug, Raw materials, Industrial products.
    • EPA CPDat observed this chemical in 25 composition records across product categories including Food and drug, Raw materials, Industrial products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    No EFSA opinion on file.

Evidence & sources

No graded research studies for 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2025-06-18

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2022-09-19

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

ntp.niehs.nih.gov

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF in a product composition. These are source records, not Greenveil catalog products.

Source records

25

Named organisations

1

Food and drugRaw materialsIndustrial products
See products using 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF →