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Drometrizole trisiloxane

CAS 320341-73-9 · 20/100 · High conf.

Also registered as 1 other CAS number

155633-54-8

Drometrizole trisiloxane chemical structure

Concern score

20/100Minor concern based on regulatory listings.
High confidence

Drometrizole trisiloxane in plain language

What it is

Also known as AKOS030621544 · EBC-27246 · Mexoryl xl · MSK21427 · Or 10154 · Silatrizole

Show all 7 names

UNII-HC22845I1X

What it does

Used in cosmetics as a UV filter and a light stabiliser. Drometrizole Trisiloxane is the heterocyclic compound.

  • UV filter
  • UV absorber
  • Light stabilizer
Is it a concern?
Minor concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

What the listings say

Permitted, with conditions — Drometrizole trisiloxane appears on published "allowed" regulatory lists rather than on a restriction list.

Phenol, 2-(2H-Benzotriazol-2-yl)-4-Methyl-6-(2-Methyl-3-(1,3,3,3-Tetramethyl-1-(Trimethylsilyl)Oxy)-Disiloxanyl)Propyl is listed in Annex VI of the EU Cosmetics Regulation (EC) 1223/2009 (UV filters allowed in cosmetic products).

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Drometrizole trisiloxane appears in these published regulatory listings.

  • In marketed US drugs
  • EU Annex VI — permitted UV filter
  • EU permitted UV filter

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • EUCosIngActive2 entries
    • Drometrizole Trisiloxane is the heterocyclic compound that conforms to the formula: Restriction: VI/16Source →
    • Cosmetics Regulation annex VI / ref 16.Source →
  • EUECallowed_listedAnnex VI of EU Cosmetics Regulation (EC) 1223/2009: UV filters allowed in cosmetic products. Maximum concentration: 15%
    • Annex VI of EU Cosmetics Regulation (EC) 1223/2009: UV filters allowed in cosmetic products. Maximum concentration: 15%Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 1 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including UV stabilizer.
    • EPA CPDat observed this chemical in 1 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including UV stabilizer.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 1 active drug products and 1 total products.
    • FDA NDC lists this ingredient in 1 active drug products and 1 total products.Source →

Expert safety opinions

No expert opinion on file for Drometrizole trisiloxane. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Drometrizole trisiloxane yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2011-03-08

    Open →

  • EPA Chemical and Products Database

    exposure · updated July 2013

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2026-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Drometrizole trisiloxane in a product composition. These are source records, not Greenveil catalog products.

Source records

1

Named organisations

3

Personal care

Typical roles

UV filterUV absorberLight stabilizer
See products using Drometrizole trisiloxane →

Catalog

Found in these products

Their ingredient lists include Drometrizole trisiloxane; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 71 →Find products without it →