- beauty
- industrial
Avotermin
CAS 182212-66-4
Concern score
Not assessed — no hazard data yet.
Avotermin in plain language
On cosmetic ingredient lists it appears as “Nicotiana benthamiana HEXAPEPTIDE-40 SH-POLYPEPTIDE-5”.
Also known as Nicotiana benthamiana HEXAPEPTIDE-40 SH-POLYPEPTIDE-5 · Human recombinant transforming growth factor .BETA.-3 · Human TGFB3 · Human transforming growth factor .BETA.-3 · Transforming growth factor BETA-3 (recombinant) · Juvista
Used in cosmetics as a skin-conditioning agent.
- Skin conditioning
- Conditioner
- We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
Regulation
No restrictions found. Avotermin appears in these published regulatory listings.
- Found in consumer products
- Industrial
EUCosIngActiveNicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-5 is a fusion peptide of Hexapeptide-40 with a single chain recombinant human peptide produced by transgenic Nicotiana benthamiana after the transient expression or stable insertion of a copy of a human gene into its DNA. The starting human gene is synthesized to be identical to the human gene which codes for Transforming Growth Factor Beta-3 which contains a maximum of 412 amino acids and may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.
- Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-5 is a fusion peptide of Hexapeptide-40 with a single chain recombinant human peptide produced by transgenic Nicotiana benthamiana after the transient expression or stable insertion of a copy of a human gene into its DNA. The starting human gene is synthesized to be identical to the human gene which codes for Transforming Growth Factor Beta-3 which contains a maximum of 412 amino acids and may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.
- EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as protein.
- openFDA substance registry classifies this ingredient as protein.Source →
Expert safety opinions
No expert opinion on file for Avotermin. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for Avotermin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.
Where it has been recorded
How often EPA CPDat has listed Avotermin in a product composition. These are source records, not Greenveil catalog products.
Named organisations
2
Typical roles
Skin conditioningConditioner