Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
- beauty
- industrial
- pharma
D&C red no. 28
CAS 18472-87-2 · 70/100 · High conf.
Colorant · Dye
Concern score
70/100High concern based on regulatory listings.
Well researched
Why it's flagged
Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7- tetrachloro-, disodium salt (CI 45410) is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.
RestrictedEU EC — restricted
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
Restrictions first, then routine listings from published regulatory sources.
- commercial_presence
- consumer_product_presence
- cpdat_category:beauty|industrial
- definition_level:complete
- definition_type:primary
- eu_annex:III
- eu_annex:IV
- eu_cosmetic_allowed_colorant
- View source →restricted
EUEC
Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Maximum concentration: (b) 0,4 % Other conditions: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 % Conditions of use and warnings: (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever…
USFDAinactive ingredient database11 entries — 2 administration routes
- Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 1 mgSource →
- Route: ORAL; Dosage form: CAPSULE, COATED PELLETS; Potency: NASource →
- Route: ORAL; Dosage form: CAPSULE, COATED, EXTENDED RELEASE; Potency: NASource →
- Route: ORAL; Dosage form: CAPSULE, DELAYED RELEASE; Maximum daily exposure: 1 mgSource →
- Route: ORAL; Dosage form: CAPSULE, EXTENDED RELEASE; Potency: 0.2 mgSource →
- Route: ORAL; Dosage form: POWDER, FOR SOLUTION; Maximum daily exposure: 3 mgSource →
- Route: ORAL; Dosage form: POWDER, FOR SUSPENSION; Potency: 0.7 mg/5mlSource →
- Route: ORAL; Dosage form: SUSPENSION; Potency: 2.5 mg/5mlSource →
- Route: ORAL; Dosage form: TABLET; Potency: NASource →
- Route: TOPICAL; Dosage form: AEROSOL; Potency: NASource →
- Route: TOPICAL; Dosage form: SOAP; Potency: NASource →
EUECallowed_listedAnnex IV of EU Cosmetics Regulation (EC) 1223/2009: colorants allowed in cosmetic products. Conditions of use and warnings: Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Annex IV of EU Cosmetics Regulation (EC) 1223/2009: colorants allowed in cosmetic products. Conditions of use and warnings: Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acidSource →
USEPAcommercial use observedEPA CPDat observed this chemical in 162 composition records across product categories including Raw materials, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Dye.
- EPA CPDat observed this chemical in 162 composition records across product categories including Raw materials, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Dye.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Evidence
No graded sources yet for D&C red no. 28. We publish evidence only once a source is linked and reviewed — this ingredient is in the catalog, but has not been assessed.
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Good fit
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
Where it appears
Prevalence of D&C red no. 28 in our catalog (epa_cpdat).
Products
162
Brands
6
Raw materialsLaboratory suppliesPersonal careConstruction
Typical roles
ColorantDye
Found in these products
- Bath BombsCrayola · BathCritical
- L'Oréal Paris Color Riche 303 Tendre Rose LippenstiftL'OREAL NORGE AS · MakeupCritical
- Maybelline Color Sense Lifter Gloss Pearl 1L'OREAL NORGE AS · Non Food ProductsCritical
- Maybelline New York Lifter Gloss 9 Topaz LipglossL'OREAL NORGE AS · MakeupCritical
- Maybelline New York Lifter Gloss 004 Silk LipglossL'OREAL NORGE AS · MakeupCritical
- Maybelline New York Lifter Gloss 5 Petal LipglossL'OREAL NORGE AS · MakeupCritical
- Maybelline New York Lifter Gloss 2 Ice LipglossL'OREAL NORGE AS · MakeupCritical
- lip balmavonCritical
- biscuitsHigh
- staze 9to9 03 caramel rose lipstickMinor
- biscuitsHigh
- Fluoride Anticavity ToothpasteCrest · ToothpasteHigh
- nyxCritical
- Just My Type Velvetease Lip PencilMAC · Lip PencilsCritical
- estee lauder lipstickNon Food ProductsCritical
- IT'S ALL AN ILLUSIONISM Nail ColorFingerPaints · MakeupCritical
- StagesOral B,Stages · HygieneHigh
- Maybelline Superrstar Ink Crayon Run the World 80L'OREAL NORGE AS · Non Food ProductsCritical
- L'Oréal Paris Color Riche 108 Brun Cuivré Satin LippenstiftL'OREAL NORGE AS,L'Oréal · MakeupCritical
- Baume a lèvresDior · MakeupCritical
- L'Oréal Paris Color Riche 453 Rose Crème LippenstiftL'OREAL NORGE AS · MakeupCritical
- L'Oréal Paris Color Riche 258 Berry Blush LippenstiftL'OREAL NORGE AS · MakeupCritical
- L'Oreal True Match Blush PeachL'OREAL NORGE AS · Non Food ProductsHigh
- L'Oreal Color Riche Matte Obsession Moka ChicL'OREAL NORGE AS · Non Food ProductsCritical
