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Thiophanate-methyl

CAS 23564-05-8 · 100/100 · High conf.

Also registered as 2 other CAS numbers

50814-12-5 · 1135443-49-0

Thiophanate-methyl chemical structure

Concern score

100/100Critical concern driven by cmr.
High confidence

Thiophanate-methyl in plain language

What it is

Also known as O-dimethyl analog thiophanate o · Allophanic acid, 4,4'-O-PHENYLENEBIS(3-THIO-, dimethyl ester · Dimethyl 4,4'-O-PHENYLENEBIS(3-THIOALLOPHANATE) · Dimethyl (1,2-phenylenedicarbamothioyl)biscarbamate · Methyl thiophanate · Methylthiofanate

Show all 35 names

Methylthiophanate · O-BIS(3-METHOXYCARBONYL-2-THIOUREIDO)BENZENE · Thiophanate m · Thiophanate methyl · 1,2-Bis(methoxycarbonylthioureido)benzene · 1,2-di-(3-methoxycarbonyl-2-thioureido)benzene · BIS(3-THIOALLOPHANATE), DIMETHYL-4,4- (o-phenylene)- · Cercobin-m · Caligran · Cercobin methyl · Cycosin · Dimethyl (1,2-PHENYLENEBIS(IMINOCARBONOTHIOYL))BISCARBAMATE · Enovit-methyl · Easout · Enovit M · Enovit Super · Frumidor · Fungitox · Fungo · Methyl topsin · Metoben · Mildothane · Neotopsin · Spot kleen · Topsin m · Thiopan · Thiophanate-methyl (ISO) · Topsin Methyl · dimethyl 4-4'-o-phenylenebis(3-thioallophanate)

What it does

Used in consumer products as an antimicrobial.

  • Antimicrobial
Is it a concern?
Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.

Why it's flagged

  • Cmr

Thiophanate-methyl is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Mutagenic Cat. 2()

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 1047.
    • Cosmetics Regulation annex II / ref 1047.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 13 composition records across product categories including Laboratory supplies, Landscape/yard, Pesticides. EPA CPDat classifies this chemical for functional uses including Biocide.
    • EPA CPDat observed this chemical in 13 composition records across product categories including Laboratory supplies, Landscape/yard, Pesticides. EPA CPDat classifies this chemical for functional uses including Biocide.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Thiophanate-methyl. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Thiophanate-methyl yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-15

    Open →
  • EPA Chemical and Products Database

    exposure · updated September 1997

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Thiophanate-methyl in a product composition. These are source records, not Greenveil catalog products.

Source records

13

Named organisations

6

Laboratory suppliesLandscape/yardPesticides

Typical roles

Antimicrobial
See products using Thiophanate-methyl →