# 1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TGIC)

URL: https://app.greenveil.ai/ingredients/ingredient_cas_2451_62_9
Categories: beauty, industrial
Functions: Binder, Chemical reaction regulator, ingredient in powder coat (polyester) paint, Processing aids not otherwise specified, resin 2
Identifier: 2451-62-9

> 1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TGIC) is used as binder / chemical reaction regulator. Greenveil chemical-concern score: 100/100 — Critical concern driven by cmr.. Compiled from 7 published data sources.

## Safety assessment

- Chemical concern score: 100/100 — Critical concern driven by cmr.
- Confidence in this assessment: High
- Is it a concern? Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.
- Rationale: 1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TGIC) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: Active — Cosmetics Regulation annex II / ref 741.
- EU: banned — Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Mutagenic Cat. 1B()
- US: commercial use observed — EPA CPDat observed this chemical in 116 composition records across product categories including Furniture and furnishings, Construction and building materials, Tools. EPA CPDat classifies this chemical for functional uses including Processing aids not otherwise specified, Binder, Chemical reaction regulator.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as mixture.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/29208
- EU CosIng Cosmetics Regulation Annexes (updated 2010-10-21): https://ec.europa.eu/growth/tools-databases/cosing/reference/annexes/list/II
- EPA Chemical and Products Database (updated may 1, 2017): https://living-future.org/declare-products/aluminum-coil-drapery-with-epoxy-and-polyester-resin-powder-coat-finish/
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:58P91Z020D
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/17142

_Assessed by Greenveil._