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m-Tolylidene diisocyanate (Toluene diisocyanate)

CAS 26471-62-5 · 100/100 · High conf.

Also registered as 24 other CAS numbers

1321-38-6 · 26102-02-3 · 1321-39-7 · 8065-47-2 · 25321-34-0 · 29033-29-2 · 50853-47-9 · 50985-24-5 · 71215-63-9 · 72214-34-7 · 80498-23-3 · 89698-92-0 · 104213-33-4 · 110681-06-6 · 136154-22-8 · 1186289-23-5 · 1204229-13-9 · 1204746-08-6 · 1211316-67-4 · 1326716-94-2 · 1421949-89-4 · 1422250-41-6 · 1422343-79-0 · 1432062-26-4

Concern score

100/100Critical concern driven by cmr.
High confidence

m-Tolylidene diisocyanate (Toluene diisocyanate) in plain language

What it is

Also known as Toluene diisocyanate (mixed isomers) · Toluene diisocyanate · 2,4-TOULENE diisocynate · Benceno, 1,3-diisocianatometil - · Benzene, 1,3-diisocyanatomethyl- · Methyl-m-phenylene ester isocyanic acid

Show all 16 names

Methylphenylene ester isocyanic acid · Tdi · Tdi (mixed isomer) · Tdi 65 · Tdi 80 · Tdi 80/20 · Un 2078 (dot) · toluene diisocyanate (animal carcinogen by ntp) · toluenediisocyanate (mixed isomers) (sara iii) · toluenediisocyanate (mixed isomers) (sara 313) (cercla)

What it does

We don't have a plain-language description for m-Tolylidene diisocyanate (Toluene diisocyanate) yet.

Recorded functional uses: Chemical reaction regulator · Crosslinking / coupling / curing agents > diisocyanates · Feedstock, polyurethane

Is it a concern?
Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.

Why it's flagged

  • Cmr

m-Tolylidene diisocyanate (Toluene diisocyanate) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Industrial

  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Carcinogenic Cat. 2()

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 1120.
    • Cosmetics Regulation annex II / ref 1120.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 189 composition records across product categories including Construction and building materials, Raw materials, Home maintenance. EPA CPDat classifies this chemical for functional uses including No specific technical function, feedstock, polyurethane, Chemical reaction regulator.
    • EPA CPDat observed this chemical in 189 composition records across product categories including Construction and building materials, Raw materials, Home maintenance. EPA CPDat classifies this chemical for functional uses including No specific technical function, feedstock, polyurethane, Chemical reaction regulator.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as mixture.
    • openFDA substance registry classifies this ingredient as mixture.Source →

Expert safety opinions

No expert opinion on file for m-Tolylidene diisocyanate (Toluene diisocyanate). These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for m-Tolylidene diisocyanate (Toluene diisocyanate) yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-21

    Open →

  • EPA Chemical and Products Database

    exposure · updated March 8, 2019

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

Allergen profile

Canonical allergen markers detected on this ingredient. Each row is derived from the ingredient’s name or synonyms matching a known allergen class — useful when scanning a label for a specific allergy context.

  • MolluscsContains · Oral (ingested)

    Source: chemindex_name_match

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed m-Tolylidene diisocyanate (Toluene diisocyanate) in a product composition. These are source records, not Greenveil catalog products.

Source records

189

Named organisations

6

Construction and building materialsRaw materialsHome maintenanceSpecialty occupational productsIndustrial productsBatteries

Typical roles

Chemical reaction regulatorCrosslinking / coupling / curing agents > diisocyanatesFeedstock, polyurethaneNo specific technical function
See products using m-Tolylidene diisocyanate (Toluene diisocyanate) →