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5-Methoxypsoralen

CAS 298-81-7 · 100/100 · High conf.

Also registered as 2 other CAS numbers

484-20-8 · 3902-71-4

5-Methoxypsoralen chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

5-Methoxypsoralen in plain language

What it is

On cosmetic ingredient lists it appears as “Citrus aurantifolia juice”.

Also known as Citrus aurantifolia juice · Citrus aurantifolia peel extract · Citrus aurantifolia peel oil distilled · Citrus aurantifolia peel oil expressed · Citrus grandis juice · Citrus grandis leaf extract

Show all 27 names

Citrus grandis peel extract · Citrus limon leaf extract · Citrus paradisi · Citrus paradisi m. peel oil expressed · Ruta graveolens oil · X c. reticulata peel extract · Bergapten · Methoxsalen related compound a · Bergaptan · Bergaptene · Geralen · Heraclin · Majudin · 5-Methoxy psoralen · 5-Methoxy-6,7-furanocoumarin · 5-Methoxyfuranocoumarin · 5-Methoxypsoralen with ultraviolet A therapy · 5-Mop · 6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone · O-Methylbergaptol · Psoraderm

What it does

We don't have a plain-language description for 5-Methoxypsoralen yet.

Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Furocoumarines (e.g. trioxysalen (INN), 8-methoxypsoralen, 5-methoxypsoralen) except for normal content in natural essences used. In sun protection and in bronzing products, furocoumarines shall be below 1 mg/kg is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial

  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 358.
    • Cosmetics Regulation annex II / ref 358.Source →
  • EUEFSAEFSA opinionSafety and efficacy of feed additives consisting of expressed lemon oil and its fractions from Citrus limon (L.) Osbeck and of lime oil from Citrus aurantiifolia (Christm.) Swingle for use in all animal species (FEFANA asbl) (EFSA FEEDAP)
    • Safety and efficacy of feed additives consisting of expressed lemon oil and its fractions from Citrus limon (L.) Osbeck and of lime oil from Citrus aurantiifolia (Christm.) Swingle for use in all animal species (FEFANA asbl) (EFSA FEEDAP)Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    • Safety and efficacy of feed additives consisting of expressed lemon oil and its fractions from Citrus limon (L.) Osbeck and of lime oil from Citrus aurantiifolia (Christm.) Swingle for use in all animal species (FEFANA asbl) (EFSA FEEDAP)

      2021 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for 5-Methoxypsoralen yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2016-12-02

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated March 8, 2019

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed 5-Methoxypsoralen in a product composition. These are source records, not Greenveil catalog products.

Named organisations

3

See products using 5-Methoxypsoralen →

Catalog

Found in these products

Their ingredient lists include 5-Methoxypsoralen; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 31 →Find products without it →