# O-CYMEN-5-OL

URL: https://app.greenveil.ai/ingredients/ingredient_cas_3228_02_2
Categories: beauty, cleaning, pharma
Functions: Preservative, Antimicrobial, Deodorant
Identifier: 3228-02-2

> O-CYMEN-5-OL: Used in cosmetics as a preservative, an antimicrobial and a deodorant. Greenveil chemical-concern score: 20/100 — Minor concern based on regulatory listings.. Compiled from 8 published data sources.

## Safety assessment

- Chemical concern score: 20/100 — Minor concern based on regulatory listings.
- Confidence in this assessment: High
- Is it a concern? Minor concern: no hazard classifications on record. It is listed for cosmetic use in the EU.
- Rationale: 4-Isopropyl-m-cresol is listed in Annex V of the EU Cosmetics Regulation (EC) 1223/2009 (preservatives allowed in cosmetic products).

## Regulatory status

- EU: Active — Cosmetics Regulation annex V / ref 38.
- EU: Active — o-Cymen-5-ol is the substituted phenol that conforms to the formula: Restriction: V/38
- EU: allowed_listed — Annex V of EU Cosmetics Regulation (EC) 1223/2009: preservatives allowed in cosmetic products. Maximum concentration: 0.1%
- US: commercial use observed — EPA CPDat observed this chemical in 91 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative, Deodorizer.
- US: marketed drug occurrence — FDA NDC lists this ingredient in 2 active drug products and 2 total products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/28783
- EU CosIng Cosmetics Regulation Annexes (updated 2010-10-16): https://ec.europa.eu/growth/tools-databases/cosing/reference/annexes/list/V
- EPA Chemical and Products Database (updated October 2015): https://www.ewg.org/skindeep/product/667018/Alpessence_24_Hour_Renewing_Cream_%282016_formulation%29/
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA National Drug Code Directory (updated 2027-12-31): https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory-support-files
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:H41B6Q1I9L
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/18597

_Assessed by Greenveil._