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Hyaluronidase

CAS 9012-81-1

Also registered as 2 other CAS numbers

9079-81-6 · 37326-33-3

Concern score

Not assessed — no hazard data yet.

Hyaluronidase in plain language

What it is

Also known as Hyaluronoglucosaminidase · hyaluronidase type iv from bovine testes · E.c. 3.2.1.34 · E.c. 3.2.1.35 · Hyalase · Hyaluronate 4-glycanohydrolase

Show all 9 names

Hyaluronoglucosidase · Neopermease · hyalosidase

What it does

Used in cosmetics as a skin-conditioning agent. Hyaluronidase is the enzyme which catalyses hydrolysis of the glycosidic linkage of hyaluronic acid.

  • Skin conditioning
  • Conditioner
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Hyaluronidase appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • USEPAcommercial use observed2 entries
    • EPA CPDat observed this chemical in 1 composition records across product categories including unclassified products.Source →
    • EPA CPDat observed this chemical in 1 composition records across product categories including Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.Source →
  • EUCosIngActiveHyaluronidase is the enzyme which catalyses hydrolysis of the glycosidic linkage of hyaluronic acid
    • Hyaluronidase is the enzyme which catalyses hydrolysis of the glycosidic linkage of hyaluronic acidSource →

Expert safety opinions

No expert opinion on file for Hyaluronidase. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Hyaluronidase yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

3 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2019-04-29

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed Hyaluronidase in a product composition. These are source records, not Greenveil catalog products.

Source records

1

Named organisations

2

Typical roles

Skin conditioningConditioner
See products using Hyaluronidase →