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Tocopheryl retinoate

CAS 40516-48-1

Also registered as 1 other CAS number

40516-49-2

Tocopheryl retinoate chemical structure

Concern score

Not assessed — no hazard data yet.

Tocopheryl retinoate in plain language

What it is

Also known as Tretinoin tocoferil · .alpha.-tocopheryl retinoate · D-.alpha.-tocopherol retinoate · D-.alpha.-tocopheryl retinoate · L-300 · L300

Show all 16 names

N-021 · NCGC00181354-01 · Tocoretinate · Tretinoin tocoferil (JAN) · Tretinoina tocoferilo · Tretinoine tocoferil · UNII-CTD060B1SS · dl-alpha-Tocopheryl Retinoate · olcenon · tretinoinum tocoferilum

What it does

Used in cosmetics as an antioxidant, a humectant and an emollient.

  • Antioxidant
  • Humectant
  • Emollient
  • Skin conditioning
  • Conditioner
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Tocopheryl retinoate appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Antioxidant.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Antioxidant.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 1 active drug products and 1 total products.
    • FDA NDC lists this ingredient in 1 active drug products and 1 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Tocopheryl retinoate. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Tocopheryl retinoate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2019-12-20

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often FDA National Drug Code directory has listed Tocopheryl retinoate in a product composition. These are source records, not Greenveil catalog products.

Source records

1

Typical roles

AntioxidantHumectantEmollientSkin conditioningConditioner
See products using Tocopheryl retinoate →