beauty
cleaning
industrial

Sulisobenzone

CAS 4065-45-6 · 20/100 · High conf.

Also registered as 3 other CAS numbers

62121-63-5 · 197923-35-6 · 6628-37-1

Concern score

20/100Minor concern based on regulatory listings.

High confidence

Sulisobenzone in plain language

What it is: On cosmetic ingredient lists it appears as “BENZOPHENONE-4”.
Also known as BENZOPHENONE-4 · Benzophenone-5 · Sulfisobenzone · 2-BENZOYL-5-METHOXY-1-PHENOL-4-SULFONIC acid · 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC acid · 5-Benzoyl-4-hydroxy-2-methoxybenzene-1-sulfonic acid
Show all 29 names
5-benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid · Benzenesulfonic acid, 5-BENZOYL-4-HYDROXY-2-METHOXY- · Benzophenone-4; Benzophenone-5 · 1-Phenol-4-sulfonic acid, 2-benzoyl-5-methoxy- · 2-Hydroxy-4-methoxy benzophenone-5-sulfonic acid · 2-Hydroxy-4-methoxy-5-sulfobenzophenone · 2-Hydroxy-4-methoxybenzophenone-5-sulphonic acid · 2-Methoxy-4-hydroxy-5-benzoylbenzenesulfonic acid · 3-Benzoyl-4-hydroxy-6-methoxybenzenesulfonic acid · Escalol 577 · Ms 40 · Seesorb 101S · Spectra-sorb UV 284 · Sungard · Syntase 230 · Sulisobenzona · Sulisobenzonum · Uval · Uvasorb s 5 · Uvinul d 5030 · Uvinul ms 40 · Uvinuc ms 40 · Viosorb 111
What it does: Used in cosmetics as a UV filter and a light stabiliser.
UV filter
UV absorber
Light stabilizer
Fragrance
Is it a concern?: Minor concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

What the listings say

Permitted, with conditions — Sulisobenzone appears on published "allowed" regulatory lists rather than on a restriction list.

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (Benzophenone-5) and its sodium salt / Sulisobenzone is listed in Annex VI of the EU Cosmetics Regulation (EC) 1223/2009 (UV filters allowed in cosmetic products).

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Sulisobenzone appears in these published regulatory listings.

EU Annex VI — permitted UV filter
EU permitted UV filter

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Industrial

EUCosIngActive2 entries
- Cosmetics Regulation annex VI / ref 22.Source →
- Benzophenone-4 is a benzophenone derivative that conforms to the formula: Restriction: VI/22Source →
EUECallowed_listedAnnex VI of EU Cosmetics Regulation (EC) 1223/2009: UV filters allowed in cosmetic products. Maximum concentration: 5%(as acid)
- Annex VI of EU Cosmetics Regulation (EC) 1223/2009: UV filters allowed in cosmetic products. Maximum concentration: 5%(as acid)Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 1990 composition records across product categories including Cleaning products and household care, Personal care, Home maintenance. EPA CPDat classifies this chemical for functional uses including UV stabilizer, Fragrance.
- EPA CPDat observed this chemical in 1990 composition records across product categories including Cleaning products and household care, Personal care, Home maintenance. EPA CPDat classifies this chemical for functional uses including UV stabilizer, Fragrance.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Sulisobenzone. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.

Evidence & sources

No graded research studies for Sulisobenzone yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2010-10-15
Open →
EPA Chemical and Products Database
exposure · updated september 8, 2015
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Sulisobenzone in a product composition. These are source records, not Greenveil catalog products.

Source records

1,990

Named organisations

Cleaning products and household carePersonal careHome maintenanceRaw materials

Typical roles

UV filterUV absorberLight stabilizerFragrance

See products using Sulisobenzone →

Catalog

Found in these products

Their ingredient lists include Sulisobenzone; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 234 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Sulisobenzone in the catalog.