Fragrance avoidance
Not a strong fit for fragrance avoidance because it carries Fragrance.
The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.
- beauty
- cleaning
- industrial
1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one; (Z)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one
CAS 43052-87-5 · 70/100 · High conf.
Also registered as 8 other CAS numbers
72748-70-0 · 23696-85-7 · 23726-91-2 · 23726-92-3 · 23726-94-5 · 24720-09-0 · 57378-68-4 · 71048-82-3
Concern score
70/100High concern based on regulatory listings.
High confidence
1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one; (Z)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one in plain language
On cosmetic ingredient lists it appears as “Alpha-damascone”.
Also known as Alpha-damascone · Cis-rose KETONE-2 · Delta-damascone · Rose KETONE-3 · Rose KETONE-4 · Rose ketone 3 (delta-Damascone)
Show all 30 names
Rose ketone 4 (Damascone) · Trans-rose KETONE-2 · Trans-rose KETONE-3 · cis-Rose ketone 1 · cis-Rose ketone 2 (cis-beta-Damascone) · trans-Rose ketone 1 · trans-Rose ketone 2 (trans-beta-Damascone) · .alpha.-damascone · 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone · (±)-.alpha.-damascone · .alpha.-damascone mixture of cis and trans isomers · 1-(2,6,6-Trimethylcyclohex-2-en-1-yl)but-2-en-1-one · Damascone alpha · (+/-)-.alpha.-damascone · (E)-1-(2,6,6-Trimethyl-2-Cyclohexen-1-yl)-2-Buten-1-one · (Z)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one · 1-(2,6,6-Trimethyl-1,3-cyclohexadienyl)-2-buten-1-one · 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-buten-1-one · 1-(2,6,6-Trimethyl-3-cyclohexenyl)-2-buten-1-one · 2-Buten-1-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)- · 2-Buten-1-one, 1-(2,6,6-trimethyl-3-cyclohexen-1-yl)- · 4-(2,6,6-Trimethyl-2-cyclohexenyl)-2-buten-4-one · alpha-1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-buten-1-one · buten-1-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-
Used in cosmetics as a fragrance ingredient.
- Perfuming
- Fragrance
- Flavouring
- Deodorant
- High concern: no hazard classifications on record. It is restricted in EU cosmetics.
Why it's flagged
1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one; (Z)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.
RestrictedEU EC — restricted
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
Restrictions first, then routine listings from published regulatory sources.
- EU Annex III — restricted
- EU restricted in cosmetics
- Found in consumer products
- Beauty
- Cleaning
- Industrial
- View source →restricted
EUEC
Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: (a) Oral products (b) Other products Maximum concentration: (b) 0.02% Other conditions: (a) (b) The presence of the substance or substances shall be indicated as ‘Rose Ketones’ in the list of ingredients referred to in Article 19(1), point (g), when the concentration of the substance or substances exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products.
USEPAcommercial use observedEPA CPDat observed this chemical in 3 composition records across product categories including Cleaning products and household care, Cleaning and safety. EPA CPDat classifies this chemical for functional uses including Fragrance, Deodorizer, Flavouring and nutrient.
- EPA CPDat observed this chemical in 3 composition records across product categories including Cleaning products and household care, Cleaning and safety. EPA CPDat classifies this chemical for functional uses including Fragrance, Deodorizer, Flavouring and nutrient.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as mixture.
- openFDA substance registry classifies this ingredient as mixture.Source →
Expert safety opinions
No expert opinion on file for 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one; (Z)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one; (Z)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2023-09-15
- Open →
EPA Chemical and Products Database
exposure · updated February 8, 2019
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Avoid
Where it has been recorded
How often EPA CPDat has listed 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one; (Z)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one in a product composition. These are source records, not Greenveil catalog products.
Source records
3
Named organisations
6
Cleaning products and household careCleaning and safety
Typical roles
PerfumingFragranceFlavouringDeodorant
Found in these products
Cosmetic and personal-care products that list 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one; (Z)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one are shown first. Their ingredient lists include 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one; (Z)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; each product's own rating depends on its whole formula, so it is shown on the product page, not here.
