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Propyphenazone

CAS 479-92-5 · 100/100 · High conf.

Also registered as 3 other CAS numbers

12542-35-7 · 88205-06-5 · 128065-64-5

Propyphenazone chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Propyphenazone in plain language

What it is

Also known as Isopropylantipyrine · Propyphenazone (INN) · 1,5-dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one · 1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one · 1-Phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one · 2,3-Dimethyl-4-isopropyl-1-phenyl-3H-pyrazolin-5-one

Show all 20 names

4-ISOPROPYL-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE · 4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one · 4-Isopropylantipyrine · 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one · Isopropylphenazone · Isopropylantipyrin · Isopropylantipyrinum · Isopropyrine · N02BB04 · Propifenazona · Propifenazone · Propyphenazonum · Yoshipyrin · propylphenazone

What it does

We don't have a plain-language description for Propyphenazone yet.

Recorded functional uses: Pharmaceutical

Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Propyphenazone (INN) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 138.
    • Cosmetics Regulation annex II / ref 138.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Pharmaceutical.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Pharmaceutical.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 1 active drug products and 1 total products.
    • FDA NDC lists this ingredient in 1 active drug products and 1 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Propyphenazone. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Propyphenazone yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-20

    Open →
  • EPA Chemical and Products Database

    exposure · updated November 2007

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2026-12-31

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Propyphenazone in a product composition. These are source records, not Greenveil catalog products.

Source records

1

Typical roles

Pharmaceutical
See products using Propyphenazone →