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Daidzein

CAS 486-66-8 · 70/100 · High conf.

Daidzein chemical structure

Concern score

70/100High concern based on regulatory listings.
High confidence

Daidzein in plain language

What it is

Also known as 7,4'-Dihydroxyisoflavone · 4',7-DIHYDROXYISOFLAVONE · 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one · 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one · 4',7-dihydroxy-isoflavon · 4,7-Dihydroxyisoflavone

Show all 19 names

4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)- · 7-Hydroxy-3-(4-hydroxy-phenyl)-chromen-4-one · 7-Hydroxy-3-(4-hydroxyphenyl)-4-benzopyron · 7-hidroxi-3-(4-hidroxifenil)-4-benzopirona · 7-hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone · 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one · Daidzein (Standard) · Daidzeol · Diadzein · Isoflavone, 4',7-dihydroxy- (8CI) · Daidzein (constituent of astragalus) · Daidzein (constituent of red clover) · Daidzein (constituent of soy isoflavones)

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
  • Conditioner
Is it a concern?
High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

Daidzeol; 4',7-Dihydroxyisoflavone; 7-hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Maximum concentration: 0,02 % Other conditions: From 1 February 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not complying with the conditions shall not be made available on the Union market.

    restricted
    View source →
  • EUCosIngActive2 entries
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Daidzein. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Daidzein yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2024-04-04

    Open →
  • EPA Chemical and Products Database

    exposure · updated February 2011

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

en.wikipedia.org

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Daidzein in a product composition. These are source records, not Greenveil catalog products.

Named organisations

3

Typical roles

Skin conditioningConditioner
See products using Daidzein →