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  • industrial

HC Blue no.16

CAS 502453-61-4 · 70/100 · High conf.

HC Blue no.16 chemical structure

Concern score

70/100High concern based on regulatory listings.
High confidence

HC Blue no.16 in plain language

What it is

On cosmetic ingredient lists it appears as “Hc blue no. 16”.

Also known as Hc blue no. 16 · HC Blue 16 · A015035 · Bluequat bromide · HC Azul 16 · HC Bleu 16

Show all 9 names

HC Blu 16 · Q27264405 · UNII-6A8OGM5UU7

What it does

Used in cosmetics as a colourant and a hair dye.

  • Colorant
  • Hair dyeing
  • Colourant
Is it a concern?
High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

1-Propanaminium, 3-[[9,10-dihydro- 4-(methylamino)- 9,10-dioxo-1- anthracenyl] amino]-N,N- dimethyl-N- propyl-, bromide is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial

  • EUEC

    Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: Hair dye substance in non-oxidative hair dye products Maximum concentration: 3,0 % Other conditions: — Do not use with nitrosating agents — Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers

    restricted
    View source →
  • EUCosIngActive2 entries
    • Cosmetics Regulation annex III / ref 282.Source →
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for HC Blue no.16. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for HC Blue no.16 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2014-06-16

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2020-02-13

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Catalog

Found in these products

Cosmetic and personal-care products that list HC Blue no.16 are shown first. Their ingredient lists include HC Blue no.16; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 8 →Find products without it →