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(-)-Epichlorohydrin

CAS 51594-55-9 · 100/100 · High conf.

(-)-Epichlorohydrin chemical structure

Concern score

100/100Critical concern driven by cmr.
High confidence

(-)-Epichlorohydrin in plain language

What it is

Also known as R-1-Chloro-2,3-epoxypropane · Epichlorohydrin · (2R)-2-(Chloromethyl)oxirane · (r)-(-)-epichlorohydrin · (2R)-(-)-3-Chloro-1,2-propenoxide · (R)-(-)-Epichlorohydrin, 99%

Show all 18 names

(r)-(chloromethyl)oxirane · (R)-2-(Chloromethyl)Oxirane · (R)-3-chloro-1,2-epoxypropane · (R)-Chloromethyloxirane · (R)-Epichlorohydrin · 2-(Chloromethyl)oxirane # · 5-17-01-00020 (Beilstein Handbook Reference) · Brlqwzuytzbjkn-vkhmyheasa-n · Oxirane, (chloromethyl)-, (2R)- · Oxirane, (chloromethyl)-, (R)- · Oxirane, 2-(chloromethyl)-, (2R)- · UNII-VEC01H609I

What it does

We don't have a plain-language description for (-)-Epichlorohydrin yet.

Is it a concern?
Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.

Why it's flagged

  • Cmr

R-1-Chloro-2,3-epoxypropane is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Carcinogenic Cat. 1B()

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 658.
    • Cosmetics Regulation annex II / ref 658.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 2 total products.
    • FDA NDC lists this ingredient in 2 active drug products and 2 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for (-)-Epichlorohydrin. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for (-)-Epichlorohydrin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-21

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2020-02-13

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed (-)-Epichlorohydrin in a product composition. These are source records, not Greenveil catalog products.

Source records

2

See products using (-)-Epichlorohydrin →