# 5-Fluorouracil

URL: https://app.greenveil.ai/ingredients/ingredient_cas_51_21_8
Categories: beauty, cleaning, food, pharma
Identifier: 51-21-8

> 5-Fluorouracil. Greenveil chemical-concern score: 100/100 — Critical concern based on regulatory listings.. Assessed from 7 sources.

## Safety assessment

- Chemical concern score: 100/100 — Critical concern based on regulatory listings.
- Confidence: 4
- Rationale: Fluorouracil (INN) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: banned — Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.
- US: commercial use observed — EPA CPDat observed this chemical in 10 composition records across product categories including Food and drug, Personal care.
- US: marketed drug occurrence — FDA NDC lists this ingredient in 46 active drug products and 46 total products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

_Assessed by Greenveil._