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Epinephrine (INN)

CAS 51-43-4 · 100/100 · High conf.

Also registered as 2 other CAS numbers

104655-05-2 · 51028-73-0

Epinephrine (INN) chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Epinephrine (INN) in plain language

What it is

Also known as Epinephrine · Adrenaline · (-)-Epinephrine · (-)-(R)-Epinephrine · Glauposine · Nephridine

Show all 44 names

Racepinefrine, (r)- · Sus-phrine sulphite-free · (-)-epinephrine epa rpt qty: 1000 lbs dot rpt qty: 1000 lbs · (R)-Adrenaline · 4-((1R)-1-HYDROXY-2-(METHYLAMINO)ETHYL)-1,2-BENZENEDIOL · Adrenalin · Anapen · Adnephrine · Adrenine · Bronkaid mist · Chelafrin · Epipen · Epinefrina · Epinephran · Epirenan · Hemisine · Hemostasin · Hypernephrin · Levoepinephrine · Levorenin · Levorenine · Neffy · Primatene mist · Renoform · Renostypticin · Sus-phrine · Sus-phrine sulfite-free · Susphrine · Symjepi · Twinject · epinephrine (cercla) · epinephrine (sara iii) · l-Adrenaline · Adrenalinum · Iontocaine component epinephrine · Lidosite topical system kit component epinephrine · Octocaine component epinephrine · epinephrine (sara iii) in aqueous solution.

What it does

We don't have a plain-language description for Epinephrine (INN) yet.

Recorded functional uses: Pharmaceutical

Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Epinephrine (INN) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 14.
  • USEPAcommercial use observedEPA CPDat observed this chemical in 52 composition records across product categories including Food and drug, Medical/dental, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Pharmaceutical.
    • EPA CPDat observed this chemical in 52 composition records across product categories including Food and drug, Medical/dental, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Pharmaceutical.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 248 active drug products and 264 total products.
    • FDA NDC lists this ingredient in 248 active drug products and 264 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Epinephrine (INN). These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    No EFSA opinion on file.

Evidence & sources

No graded research studies for Epinephrine (INN) yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-15

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2020-08-31

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2030-10-31

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (5)
Openfda substance

accessdata.fda.gov

Openfda substance

eurofinsdiscovery.com

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Epinephrine (INN) in a product composition. These are source records, not Greenveil catalog products.

Source records

264

Typical roles

Pharmaceutical
See products using Epinephrine (INN) →