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Blood group rh(d) polypeptide

CAS 52500-60-4

Concern score

Not assessed — no hazard data yet.

Blood group rh(d) polypeptide in plain language

What it is

On cosmetic ingredient lists it appears as “RH-POLYPEPTIDE-2”.

Also known as RH-POLYPEPTIDE-2 · Thioredoxins · CD240D · Rh polypeptide 2 · Rhd antigen · Rhesus d antigen

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
  • Conditioner
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Blood group rh(d) polypeptide appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUCosIngActiverh-Polypeptide-2 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Thioredoxin. It contains a maximum of 105 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids Restriction: II/416
    • rh-Polypeptide-2 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Thioredoxin. It contains a maximum of 105 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids Restriction: II/416Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as protein.
    • openFDA substance registry classifies this ingredient as protein.Source →

Expert safety opinions

No expert opinion on file for Blood group rh(d) polypeptide. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Blood group rh(d) polypeptide yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2019-12-31

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
Reference links (1)

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed Blood group rh(d) polypeptide in a product composition. These are source records, not Greenveil catalog products.

Named organisations

1

Typical roles

Skin conditioningConditioner
See products using Blood group rh(d) polypeptide →