Skip to content
  • beauty
  • industrial

Tetraaminopyrimidine sulfate

CAS 5392-28-9 · 70/100 · High conf.

Also registered as 1 other CAS number

49647-58-7

Tetraaminopyrimidine sulfate chemical structure

Concern score

70/100High concern based on regulatory listings.
High confidence

Tetraaminopyrimidine sulfate in plain language

What it is

Also known as 2,4,5,6-Pyrimidinetetramine sulfate (1:1) · 2,4,5,6-Tetraaminopyrimidine sulphate · Sulfuric acid--pyrimidine-2,4,5,6-tetramine (1/1) · pyrimidine-2,4,5,6-tetramine;sulfuric acid · 2,4,5,6-Pyrimidinetetramine, sulfate (1:1) · 2,4,5,6-Pyrimidinetetramine, sulfate (1:?)

Show all 16 names

2,4,5,6-Tetraaminopyrimidine sulfate · 2,4,5,6-Tetraaminopyrimidine sulfate (1:1) · Pyrimidine, tetraamino-, sulfate (1:1) · Pyrimidine-2,4,5,6-tetraamine sulfate · sulfate Pyrimidinetetramine · Pyrimidinetetramine, sulfate (1:1) · Pyrimidintetrayltetraaminsulfat · Sulfate de pyrimidinetetrayltetraamine · pyrimidinetetrayltetraamine sulphate · tetra-Aminopyrimidine sulfate

What it does

Used in cosmetics as a hair dye.

  • Hair dyeing
  • Colourant
Is it a concern?
High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

2,4,5,6-Tetraaminopyrimidine sulphate is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products (c) Products in­tended for col­ouring eyelashes Maximum concentration: (b) 3,4% (calculated as sulphate) Other conditions: (a) (c) After mixing under oxidative condit­ions the maximum concentration ap­plied to hair or eye­lashes must not ex­ceed 3,4 % (calcu­lated as sulfate) (c) Professional use Conditions of use and warnings: (a) To be printed on the la­bel: The mixing ratio. “Hair colourants can cause severe allergic reac­tions. Read and follow instruc­tions. This product is not in­tended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irri­tated and damaged scalp, — you…

    restricted
    View source →
  • EUCosIngActive2 entries
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Tetraaminopyrimidine sulfate. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Tetraaminopyrimidine sulfate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2020-07-27

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2020-02-13

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.