Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
CAS 5392-28-9 · 70/100 · High conf.
49647-58-7
Concern score
Also known as 2,4,5,6-Pyrimidinetetramine sulfate (1:1) · 2,4,5,6-Tetraaminopyrimidine sulphate · Sulfuric acid--pyrimidine-2,4,5,6-tetramine (1/1) · pyrimidine-2,4,5,6-tetramine;sulfuric acid · 2,4,5,6-Pyrimidinetetramine, sulfate (1:1) · 2,4,5,6-Pyrimidinetetramine, sulfate (1:?)
2,4,5,6-Tetraaminopyrimidine sulfate · 2,4,5,6-Tetraaminopyrimidine sulfate (1:1) · Pyrimidine, tetraamino-, sulfate (1:1) · Pyrimidine-2,4,5,6-tetraamine sulfate · sulfate Pyrimidinetetramine · Pyrimidinetetramine, sulfate (1:1) · Pyrimidintetrayltetraaminsulfat · Sulfate de pyrimidinetetrayltetraamine · pyrimidinetetrayltetraamine sulphate · tetra-Aminopyrimidine sulfate
Used in cosmetics as a hair dye.
2,4,5,6-Tetraaminopyrimidine sulphate is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.
RestrictedEU EC — restricted
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Restrictions first, then routine listings from published regulatory sources.
EUEC
Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products (c) Products intended for colouring eyelashes Maximum concentration: (b) 3,4% (calculated as sulphate) Other conditions: (a) (c) After mixing under oxidative conditions the maximum concentration applied to hair or eyelashes must not exceed 3,4 % (calculated as sulfate) (c) Professional use Conditions of use and warnings: (a) To be printed on the label: The mixing ratio. “Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you…
No expert opinion on file for Tetraaminopyrimidine sulfate. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
No graded research studies for Tetraaminopyrimidine sulfate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
CosIng
regulatory · updated 2026-09-23
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2020-07-27
EPA Chemical and Products Database
exposure · updated 2020-02-13
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
FDA GSRS UNII
registry · updated 2026-02-26
openFDA Substance
registry · updated 2026-05-24
PubChem Live Enrichment
chemistry · updated 2026-05-17
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.