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Tetrahydropyranyloxy phenol

CAS 53936-56-4 · 100/100 · High conf.

Tetrahydropyranyloxy phenol chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Tetrahydropyranyloxy phenol in plain language

What it is

Also known as Deoxyarbutin · 4-(oxan-2-yloxy)phenol · Tetrahydropyranyloxy phenol, (±)- · (+/-)-tetrahydropyranyloxy phenol · (±)-tetrahydropyranyloxy phenol · 4-((2-TETRAHYDROPYRANYL)OXY)PHENOL

Show all 13 names

4-((Tetrahydro-2H-pyran-2-yl)oxy)phenol · 4-(TETRAHYDRO-2H-PYRAN-2-YLOXY)PHENOL · 4-HYDROXYPHENYL tetrahydropyranyl ether · D-arbutin · Girlite da 100 · Tetrahydropyranyloxy phenol, (+/-)- · UNII-RG969BY5EN

What it does

Used in cosmetics as a bleaching agent.

  • Bleaching
  • Bleaching agent
Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol (Deoxyarbutin, Tetrahydropyranyloxy Phenol) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActive2 entries
    • Cosmetics Regulation annex II / ref 1657.Source →
    • Tetrahydropyranyloxy Phenol (also known as Deoxyarbutin) is the organic compound that conforms to the formula: Restriction: II/1657Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Bleaching agent.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Bleaching agent.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Tetrahydropyranyloxy phenol. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Tetrahydropyranyloxy phenol yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2021-07-06

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2019-12-20

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Tetrahydropyranyloxy phenol in a product composition. These are source records, not Greenveil catalog products.

Named organisations

1

Typical roles

BleachingBleaching agent
See products using Tetrahydropyranyloxy phenol →