# Ethyl bis(4-hydroxy-2-oxo-1-benzopyran-3-yl)acetate and salts of the acid

URL: https://app.greenveil.ai/ingredients/ingredient_cas_548_00_5
Categories: beauty, industrial
Identifier: 548-00-5

> Ethyl bis(4-hydroxy-2-oxo-1-benzopyran-3-yl)acetate and salts of the acid. Greenveil chemical-concern score: 100/100 — Critical concern based on regulatory listings.. Compiled from 7 published data sources.

## Safety assessment

- Chemical concern score: 100/100 — Critical concern based on regulatory listings.
- Confidence in this assessment: High
- Is it a concern? Critical concern: no hazard classifications on record. It is banned in EU cosmetics.
- Rationale: Ethyl bis(4-hydroxy-2-oxo-1-benzopyran-3-yl)acetate and salts of the acid is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: Active — Cosmetics Regulation annex II / ref 204.
- EU: banned — Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.
- US: commercial use observed — EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/29686
- EU CosIng Cosmetics Regulation Annexes (updated 2010-10-20): https://ec.europa.eu/growth/tools-databases/cosing/reference/annexes/list/II
- EPA Chemical and Products Database (updated 2020-08-31): https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:08KL644731
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/54685524

_Assessed by Greenveil._