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Isoniazid

CAS 54-85-3 · 100/100 · High conf.

Also registered as 4 other CAS numbers

7640-37-1 · 37271-10-6 · 41466-07-3 · 62229-51-0

Isoniazid chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Isoniazid in plain language

What it is

On cosmetic ingredient lists it appears as “Adipic acid dihydrazide”.

Also known as Adipic acid dihydrazide · Stearic hydrazide · Isonicotinic acid hydrazide · 4-PYRIDINECARBOXYLIC acid hydrazide · Hydrazides and their salts e.g. Isoniazid (INN) · 4-PYRIDINECARBOXYLIC acid, hydrazide

Show all 46 names

Armazid · Armazide · Atcotibine · Cedin · Cotinazin · Dianicotyl · Dinacrin · Ditubin · Eralon · Ertuban · Hidrasonil · Hydrazid · Ipcazide · Isidrina · Isobicina · Isonicotan · Mybasan · Neumandin · Pyridine-4-carbohydrazide · Teebaconin · Tisiodrazida · 4-(Hydrazinocarbonyl)pyridine · 4-Pyridinecarbonylhydrazine · 4-Pyridinecarboxylic acid hydrazine · 4-Pyridinecarboxylic hydrazide · 4-Pyridylcarbonylhydrazide · Dow-isoniazid · Hyzyd · Inh · Iscotin · Isonicotinylhydrazine · Isoniazide · Isonicotinohydrazide · Laniazid · Nydrazid · Rimifon · Stanozide · hydrazide · Rifamate component isoniazid · Rifater component isoniazid

What it does

We don't have a plain-language description for Isoniazid yet.

Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Hydrazides and their salts e.g. Isoniazid (INN) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Pharma
  • Food
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 200.
    • Cosmetics Regulation annex II / ref 200.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 4 composition records across product categories including Food and drug, Laboratory supplies.
    • EPA CPDat observed this chemical in 4 composition records across product categories including Food and drug, Laboratory supplies.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 16 active drug products and 29 total products.
    • FDA NDC lists this ingredient in 16 active drug products and 29 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Isoniazid. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    No EFSA opinion on file.

Evidence & sources

No graded research studies for Isoniazid yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-20

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2020-08-31

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2028-02-28

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (3)

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Isoniazid in a product composition. These are source records, not Greenveil catalog products.

Source records

29

See products using Isoniazid →