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N,N'-Methylenedimorpholine; N,N'-methylenebismorpholine; [formaldehyde released from N,N'-Methylenebismorpholine]; [MBM] if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is = 0,1 % w/w

CAS 5625-90-1 · 100/100 · High conf.

N,N'-Methylenedimorpholine; N,N'-methylenebismorpholine; [formaldehyde released from N,N'-Methylenebismorpholine]; [MBM] if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is = 0,1 % w/w chemical structure

Concern score

100/100Critical concern driven by cmr.
High confidence

N,N'-Methylenedimorpholine; N,N'-methylenebismorpholine; [formaldehyde released from N,N'-Methylenebismorpholine]; [MBM] if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is = 0,1 % w/w in plain language

What it is

Also known as Bis(morpholino-)methan · 4,4'-METHYLENEBISMORPHOLINE · 4,4-Methylenedimorpholine · Dimorpholinomethane · 4,4'-Methylenebis(morpholine) · 4-(morpholin-4-ylmethyl)morpholine

Show all 17 names

4,4'-Methylenedimorpholine · 4,4-methylene-bismorpholine · Bis(morpholino)methane · Bismorpholino methane · Methylenebismorpholine · Morpholine, 4,4'-METHYLENEDI- · Morpholine, 4,4'-methylenebis- · N,N'-Dimorpholinomethane · bis(4-morpholinyl)methane · methylene dimorpholine · n,n'-methylenebismorpholine

What it does

Used in consumer products as a preservative.

  • Preservative
Is it a concern?
Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.

Why it's flagged

  • Cmr

N,N'-Methylenedimorpholine; N,N'-methylenebismorpholine; [formaldehyde released from N,N'-Methylenebismorpholine]; [MBM] if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is = 0,1 % w/w is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Carcinogenic Cat. 1B(),Mutagenic Cat. 2()

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 1605.
    • Cosmetics Regulation annex II / ref 1605.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 5 composition records across product categories including Industrial products, Home maintenance. EPA CPDat classifies this chemical for functional uses including Preservative.
    • EPA CPDat observed this chemical in 5 composition records across product categories including Industrial products, Home maintenance. EPA CPDat classifies this chemical for functional uses including Preservative.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for N,N'-Methylenedimorpholine; N,N'-methylenebismorpholine; [formaldehyde released from N,N'-Methylenebismorpholine]; [MBM] if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is = 0,1 % w/w. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for N,N'-Methylenedimorpholine; N,N'-methylenebismorpholine; [formaldehyde released from N,N'-Methylenebismorpholine]; [MBM] if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is = 0,1 % w/w yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2020-07-30

    Open →
  • EPA Chemical and Products Database

    exposure · updated 4 December 2007

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed N,N'-Methylenedimorpholine; N,N'-methylenebismorpholine; [formaldehyde released from N,N'-Methylenebismorpholine]; [MBM] if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is = 0,1 % w/w in a product composition. These are source records, not Greenveil catalog products.

Source records

5

Named organisations

3

Industrial productsHome maintenance

Typical roles

Preservative
See products using N,N'-Methylenedimorpholine; N,N'-methylenebismorpholine; [formaldehyde released from N,N'-Methylenebismorpholine]; [MBM] if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is = 0,1 % w/w →