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Probenecid

CAS 57-66-9 · 100/100 · High conf.

Also registered as 1 other CAS number

1384172-26-2

Probenecid chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Probenecid in plain language

What it is

Also known as Probenecid (INN) · 4-(Dipropylsulfamoyl)benzoic acid · Benzoic acid, 4-((DIPROPYLAMINO)SULFONYL)- · P-(dipropylsulfamoyl)benzoic acid · Probenate · 4-(Dipropylaminosulfonyl)benzoic acid

Show all 28 names

4-(N,N-Dipropylaminosulfonyl)benzoic acid · Apurina · Benecid · Benemid · Benuryl · Probalan · Probecid · Proben · Probenecid acid · Probenecida · Probenecide · Probenemid · Prolongine · Synergid R · Tubophan · Uricosid · Col-probenecid component probenecid · Colbenemid component probenecid · Probampacin component probenecid · Proben-c component probenecid · Orlynvah component probenecid · Probenecidum

What it does

We don't have a plain-language description for Probenecid yet.

Recorded functional uses: Masking agents

Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Probenecid (INN) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial

  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 161.
    • Cosmetics Regulation annex II / ref 161.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Masking agents.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Masking agents.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 12 active drug products and 12 total products.
    • FDA NDC lists this ingredient in 12 active drug products and 12 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Probenecid. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Probenecid yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-20

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2020-08-31

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

accessdata.fda.gov

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Probenecid in a product composition. These are source records, not Greenveil catalog products.

Source records

12

Typical roles

Masking agents
See products using Probenecid →