# DIPHENHYDRAMINE HYDROCHLORIDE

URL: https://app.greenveil.ai/ingredients/ingredient_cas_58_73_1
Categories: beauty, food, industrial, pharma
Functions: Pharmaceutical, Softener and conditioner
Identifier: 58-73-1

> DIPHENHYDRAMINE HYDROCHLORIDE is used as pharmaceutical / softener and conditioner. Greenveil chemical-concern score: 100/100 — Critical concern based on regulatory listings.. Assessed from 7 sources.

## Safety assessment

- Chemical concern score: 100/100 — Critical concern based on regulatory listings.
- Confidence: 4
- Rationale: Diphenhydramine (INN) and its salts is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: banned — Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.
- US: commercial use observed — EPA CPDat observed this chemical in 35 composition records across product categories including Food and drug, Raw materials, Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Pharmaceutical.
- US: marketed drug occurrence — FDA NDC lists this ingredient in 975 active drug products and 1063 total products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

_Assessed by Greenveil._