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  • beauty
  • industrial

2-[bis(2-Hydroxye­thyl)amino]-5-nitro­phenol

CAS 59820-43-8 · 70/100 · High conf.

Concern score

70/100High concern based on regulatory listings.
High confidence

2-[bis(2-Hydroxye­thyl)amino]-5-nitro­phenol in plain language

What it is

On cosmetic ingredient lists it appears as “Hc yellow no. 4”.

Also known as Hc yellow no. 4 · HC Yellow 4 · HC Yellow No 4

What it does

Used in cosmetics as a hair dye. HC Yellow No. 4 is the hair color.

  • Hair dyeing
  • Colourant
Is it a concern?
High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

2-[bis(2-Hydroxye­thyl)amino]-5-nitro­phenol is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUCosIngActive2 entries
    • Cosmetics Regulation annex III / ref 253.Source →
    • HC Yellow No. 4 is the hair color that conforms to the formula: Restriction: Annex III/253Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.Source →

Expert safety opinions

No expert opinion on file for 2-[bis(2-Hydroxye­thyl)amino]-5-nitro­phenol. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for 2-[bis(2-Hydroxye­thyl)amino]-5-nitro­phenol yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

3 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2013-09-09

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2020-03-22

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Catalog

Found in these products

Cosmetic and personal-care products that list 2-[bis(2-Hydroxye­thyl)amino]-5-nitro­phenol are shown first. Their ingredient lists include 2-[bis(2-Hydroxye­thyl)amino]-5-nitro­phenol; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 4 →Find products without it →