Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
CAS 612-82-8 · 100/100 · High conf.
Concern score
Also known as O-tolidine dihydrochloride · 3,3'-Dimethylbenzidine dihydrochloride · Benzidine, 3,3'-DIMETHYL-, dihydrochloride · 2,3'-Dimethylbiphenyl-4,4'-diamine dihydrochloride · 3,3'-Dimethylbenzidene dihydrochloride · 3,3'-Dimethylbenzidine.2HCl
3,3’-Dimethylbenzidine 2HCl · 4,4'-Diamino-3,3'-dimethylbiphenyl dihydrochloride · AAA61282 · o-tolidine dihydrochloride cas 612-82-6 · o-tolidine dihyrochloride · ortho-tolidine dihydrochloride hydrate · orthotolidine dihydrochloride
We don't have a plain-language description for 4,4'-Bi-o-toluidine dihydrochloride yet.
4,4'-Bi-o-toluidine dihydrochloride is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.
RestrictedEU EC — banned
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Restrictions first, then routine listings from published regulatory sources.
EUEC
Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Carcinogenic Cat. 1B()
No expert opinion on file for 4,4'-Bi-o-toluidine dihydrochloride. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
No graded research studies for 4,4'-Bi-o-toluidine dihydrochloride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
CosIng
regulatory · updated 2026-09-23
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2010-10-15
EPA Chemical and Products Database
exposure · updated March 8, 2019
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
FDA GSRS UNII
registry · updated 2026-02-26
openFDA Substance
registry · updated 2026-05-24
PubChem Live Enrichment
chemistry · updated 2026-05-17
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
How often EPA CPDat has listed 4,4'-Bi-o-toluidine dihydrochloride in a product composition. These are source records, not Greenveil catalog products.
Source records
15
Named organisations
3