# 3-Amino-7- (dimethylamino)-2- methoxyphenoxazin- 5-ium chloride

URL: https://app.greenveil.ai/ingredients/ingredient_cas_67846_56_4
Categories: beauty, industrial
Functions: Hair dyeing, Colourant
Identifier: 67846-56-4

> 3-Amino-7- (dimethylamino)-2- methoxyphenoxazin- 5-ium chloride: Used in cosmetics as a hair dye. Greenveil chemical-concern score: 70/100 — High concern based on regulatory listings.. Compiled from 4 published data sources.

## Safety assessment

- Chemical concern score: 70/100 — High concern based on regulatory listings.
- Confidence in this assessment: High
- Is it a concern? High concern: no hazard classifications on record. It is restricted in EU cosmetics.
- Rationale: 3-Amino-7- (dimethylamino)-2- methoxyphenoxazin- 5-ium chloride is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: Active — Cosmetics Regulation annex III / ref 305.
- EU: Active — Restriction: III/305
- EU: restricted — Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: Hair dye substance in non-oxidative hair dye products Maximum concentration: As from 3 September 2017: 0,5 % Other conditions: As from 3 September 2017: — Do not use with nitrosating agents — Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers Conditions of use and warnings: As from 3 March 2018: ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction…
- US: commercial use observed — EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/91435
- EU CosIng Cosmetics Regulation Annexes (updated 2020-07-27): https://ec.europa.eu/growth/tools-databases/cosing/reference/annexes/list/III
- EPA Chemical and Products Database (updated 2020-02-13): https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=91435
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566

_Assessed by Greenveil._