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Choline chloride

CAS 1643859-93-1 · 100/100 · High conf.

Also registered as 3 other CAS numbers

2028303-08-2 · 2690420-71-2 · 67-48-1

Choline chloride chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Choline chloride in plain language

What it is

On cosmetic ingredient lists it appears as “Defined cell culture media”.

Also known as Defined cell culture media · 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride · Choline salts and their esters e.g. choline chloride (INN) · 2-Hydroxy-N,N,N,-trimethylethanaminium chloride · 2-hydroxyethyl(trimethyl)azanium chloride · Hormocline

Show all 30 names

Lipotril · Paresan · (2-HYDROXYETHYL)TRIMETHYLAMMONIUM chloride · (β-Hydroxyethyl)trimethylammonium chloride · 2-HYDROXY-N,N,N-TRIMETHYLETHANAMINIUM chloride (1:1) · 2-Hydroxy-N,N,N-trimethylethanaminium chloride · Actiron CC 6 · Bilineurin chloride · Biocolina · Biocoline · Chloride de choline · Chlorure de choline · Choline chlorhydrate · Choline hydrochloride · Cholini chloridum · Cholinium chloride · Cloruro de colina · Colina cloruro · Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride · Hepacholine · Luridin chloride · Neocolina · Trimethyl(2-hydroxyethyl)ammonium chloride · ethanaminium, 2-hydroxy-n,n,n-trimethyl-, chloride (1:1)

What it does

Used in cosmetics as a humectant and a skin-conditioning agent.

  • Humectant
  • Skin conditioning
  • Flavouring agent
  • Surfactant
  • Flavouring
  • Conditioner
Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Choline salts and their esters e.g. choline chloride (INN) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial

  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActive2 entries
  • EUEFSAEFSA opinion2 entries
    • Scientific Opinion on safety and efficacy of choline chloride as a feed additive for all animal species (EFSA FEEDAP)Source →
    • Choline-stabilised orthosilicic acid added for nutritional purposes to food supplements (EFSA ANS)Source →
  • GLOBALJECFANo safety concern at current levels of intake when used as a flavouring agentJECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
    • JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 5 composition records across product categories including Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Surfactant (surface active agent), Anti-static agent, Humectant.
    • EPA CPDat observed this chemical in 5 composition records across product categories including Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Surfactant (surface active agent), Anti-static agent, Humectant.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Scientific Opinion on safety and efficacy of choline chloride as a feed additive for all animal species (EFSA FEEDAP)

      2011 · EU EFSA listing · Read the source →

    • Choline-stabilised orthosilicic acid added for nutritional purposes to food supplements (EFSA ANS)

      2009 · EU EFSA listing · Read the source →

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.

      Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Choline chloride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-20

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated January 7, 2008

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Choline chloride in a product composition. These are source records, not Greenveil catalog products.

Source records

5

Named organisations

6

Laboratory supplies

Typical roles

HumectantSkin conditioningFlavouring agentSurfactantFlavouringConditioner
See products using Choline chloride →

Catalog

Found in these products

Their ingredient lists include Choline chloride; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 909 →Find products without it →