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Diaminopyrimidine oxide

CAS 74638-76-9 · 70/100 · High conf.

Concern score

70/100High concern based on regulatory listings.
High confidence

Diaminopyrimidine oxide in plain language

What it is

Also known as Aminexil · 2,4-Pyrimidinediamine, 3-oxide · Kopexil · 2,4-DIAMINOPYRIMIDINE 3-N-OXIDE · 6-Amino-2-iminopyrimidin-1(2H)-ol · 2,6-Diaminopyrimidin-1-ium-1-olate

Show all 8 names

4-Pyrimidinamine, 2,3-dihydro-3-hydroxy-2-imino- · Mexoryl sag

What it does

Used in cosmetics as a skin-conditioning agent and a hair conditioner.

  • Skin conditioning
  • Hair conditioning
  • Conditioner
Is it a concern?
High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

2,4-Pyrimidinediamine, 3-oxide is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial

  • EUEC

    Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: Hair products Maximum concentration: 1.5%

    restricted
    View source →
  • EUCosIngActive2 entries
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 3 active drug products and 3 total products.
    • FDA NDC lists this ingredient in 3 active drug products and 3 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Diaminopyrimidine oxide. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Diaminopyrimidine oxide yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-11-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2020-02-13

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Diaminopyrimidine oxide in a product composition. These are source records, not Greenveil catalog products.

Source records

3

Typical roles

Skin conditioningHair conditioningConditioner
See products using Diaminopyrimidine oxide →

Catalog

Found in these products

Cosmetic and personal-care products that list Diaminopyrimidine oxide are shown first. Their ingredient lists include Diaminopyrimidine oxide; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 5 →Find products without it →