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Trimethylbenzoyl diphenylphosphine oxide

CAS 596818-40-5 · 100/100 · High conf.

Also registered as 6 other CAS numbers

743458-22-2 · 1004988-40-2 · 1266684-52-9 · 1629246-19-0 · 2378004-46-5 · 75980-60-8

Trimethylbenzoyl diphenylphosphine oxide chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Trimethylbenzoyl diphenylphosphine oxide in plain language

What it is

Also known as 2,4,6-Trimethylbenzoyl diphenylphosphine oxide · Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide · (Diphenylphosphoryl)(2,4,6-trimethylphenyl)methanone · (DIPHENYLPHOSPHINYL)(2,4,6-TRIMETHYLPHENYL)METHANONE · (Diphenylphosphoryl)(mesityl)methanone · 2,4,6-Trimethylbenzoyl-di-phenylphosphinoxid

Show all 24 names

2,4,6-Trimethylbenzoyl-diphenyl-phosphineoxide · 2,4,6-Trimethylbenzoyldiphenyl phosphine oxide · 2,4,6-Trimethylbenzoyldiphenylphosphine oxide · 2,4,6-trimethyl benzoyl diphenyl phosphine oxide · 2,4,6-trimethyl benzoyldiphenyl phosphine oxide · 2,4,6-trimethyldiphenylphosphineoxide · Additol tpo · Chivacure TPO · DIPHENYL(2,4,6-TRIMETHYLBENZOYL)PHOSPHINE · Doublecure tpo · Darocur TPO · Darocure TPO · Diphenyl(2,4,6-trimethylbenzoyl)phosphinoxid · Ec 278-355-8 · Genocure tpo · Methanone, (DIPHENYLPHOSPHINYL)(2,4,6-TRIMETHYLPHENYL)- · Phosphine oxide, diphenyl(2,4,6-trimethylbenzoyl)- · diphenylphosphoryl-(2,4,6-trimethylphenyl)methanone

What it does

Used in cosmetics as a nail sculpting agent.

  • Nail sculpting
  • Conditioner
Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide; INCI: Trimethylbenzoyl Diphenylphosphine Oxide is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActive2 entries
    • Trimethylbenzoyl Diphenylphosphine Oxide is the organic compound Restriction: II/1731Source →
    • Cosmetics Regulation annex II / ref 1731.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 187 composition records across product categories including Construction and building materials, Personal care, Construction. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, pu coating, Photosensitizers.
    • EPA CPDat observed this chemical in 187 composition records across product categories including Construction and building materials, Personal care, Construction. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, pu coating, Photosensitizers.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Trimethylbenzoyl diphenylphosphine oxide. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Trimethylbenzoyl diphenylphosphine oxide yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2025-06-18

    Open →
  • EPA Chemical and Products Database

    exposure · updated november 8, 2016

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Trimethylbenzoyl diphenylphosphine oxide in a product composition. These are source records, not Greenveil catalog products.

Source records

187

Named organisations

6

Construction and building materialsPersonal careConstruction

Typical roles

Nail sculptingConditioner
See products using Trimethylbenzoyl diphenylphosphine oxide →