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Chlorthalidone

CAS 77-36-1 · 100/100 · High conf.

Also registered as 2 other CAS numbers

74658-80-3 · 74666-82-3

Chlorthalidone chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Chlorthalidone in plain language

What it is

Also known as Chlortalidone · Chlortalidone (INN) · Natriuran · Phthalamudine · (.+-.)-Chlorthalidone · (.+-.)-Hygroton

Show all 36 names

1-Oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxy-isoindolinum · 1-Oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline · 1-Oxo-3-(4'-chloro-3'-sulphamoylphenyl)-3-hydroxyisoindoline · 1-keto-3-(3'-Sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline · 3-HYDROXY-3-(4-CHLORO-3-SULFAMYLPHENYL)PHTHALIMIDINE · Chlorothalidone · Chlorphthalidolone · Chlorphthalidone · Chlorthalidon · Clortalidona · Clortalidone · G-33182 · Hemiclor · Hygroton · Igroton · Isoren · Oradil · Phthalamodine · Renon · Saluretin · Thalitone · Zambesil · Clorpres component chlorthalidone · Combipres component chlorthalidone · Demi-regroton component chlorthalidone · Kerledex component chlorthalidone · Lopressidone component chlorthalidone · Regroton component chlorthalidone · Tenoretic component chlorthalidone · Chlortalidonum

What it does

We don't have a plain-language description for Chlorthalidone yet.

Recorded functional uses: Pharmaceutical

Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Chlortalidone (INN) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 262.
    • Cosmetics Regulation annex II / ref 262.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Pharmaceutical.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Pharmaceutical.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 117 active drug products and 121 total products.
    • FDA NDC lists this ingredient in 117 active drug products and 121 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Chlorthalidone. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Chlorthalidone yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-20

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2020-08-31

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (2)
Openfda substance

clinicalkey.com

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Chlorthalidone in a product composition. These are source records, not Greenveil catalog products.

Source records

121

Typical roles

Pharmaceutical
See products using Chlorthalidone →