# BISPHENOL A

URL: https://app.greenveil.ai/ingredients/ingredient_cas_80_05_7
Categories: beauty, food, industrial, pharma
Functions: Antioxidant
Identifier: DTXSID7020182

> BISPHENOL A: Used in cosmetics as an antioxidant. Greenveil chemical-concern score: 100/100 — Critical concern driven by cmr.. Compiled from 7 published data sources.

## Safety assessment

- Chemical concern score: 100/100 — Critical concern driven by cmr.
- Confidence in this assessment: High
- Is it a concern? Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.
- Rationale: Bisphenol A (4,4'-Isopropylidenediphenol) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: Active — Cosmetics Regulation annex II / ref 1176.
- EU: Active — 4,4'-(1-Methylethylidene)Bisphenol Restriction: II/1176
CMR 1B
- EU: banned — Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Reprotoxic Cat. 1B()
- US: commercial use observed — EPA CPDat observed this chemical in 295 composition records across product categories including Furniture and furnishings, Raw materials, Medical/dental. EPA CPDat classifies this chemical for functional uses including No specific technical function, Binder, Hardener.
- US: marketed drug occurrence — FDA NDC lists this ingredient in 7 active drug products and 13 total products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/29395
- EU CosIng Cosmetics Regulation Annexes (updated 2018-04-24): https://ec.europa.eu/growth/tools-databases/cosing/reference/annexes/list/II
- EPA Chemical and Products Database (updated february 2, 2017): https://living-future.org/declare-products/aluminum-coil-drapery-with-epoxy-and-polyester-resin-powder-coat-finish/
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA National Drug Code Directory (updated 2029-06-12): https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory-support-files
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:MLT3645I99

_Assessed by Greenveil._