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Dimethoxane

CAS 828-00-2 · 100/100 · High conf.

Also registered as 1 other CAS number

37235-59-9

Dimethoxane chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Dimethoxane in plain language

What it is

Also known as 2,6-Dimethyl-1,3-dioxan-4-yl acetate (Dimethoxane) · 2,6-Dimethyl-1,3-dioxan-4-yl acetate · 1,3-Dioxan-4-ol, 2,6-dimethyl-, 4-acetate · 1,3-Dioxan-4-ol, 2,6-dimethyl-, acetate · 2,4-Dimethyl-6-acetoxy-1,3-dioxane · 2,4-Dimethyl-6-m-dioxanyl acetate

Show all 24 names

2,6-DIMETHYL-1,3-DIOXAN-4-OL acetate · 2,6-Dimethyl-m-dioxan-4-yl acetate · 2,6-Dimethyl-meta-dioxan-4-ol acetate · 2,6-dimethyl-m-dioxan-4 ol acetate · 6-Acetoxy-2,4-dimethyl-1,3-dioxane · 6-Acetoxy-2,4-dimethyl-m-dioxane · 6-Acetoxy-2,4-dimethyl-meta-dioxane · Acetic acid, 2,6-dimethyl-m-dioxan-4-yl ester · Acetomethoxan · Acetomethoxane · Ddoa · Dioxin (bactericide) (Obs.) · G1V Gard DXN · GIV Gard DXN · GIV Gard DXN-CO · NCI-C56213 · dimethoxane(cas#828-00-2) · m-Dioxan-4-ol, 2,6-dimethyl-, acetate

What it does

Used in consumer products as a preservative and an antimicrobial.

  • Preservative
  • Antimicrobial
Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

2,6-Dimethyl-1,3-dioxan-4-yl acetate (Dimethoxane) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 368.
    • Cosmetics Regulation annex II / ref 368.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 33 composition records across product categories including Raw materials, Specialty occupational products, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative.
    • EPA CPDat observed this chemical in 33 composition records across product categories including Raw materials, Specialty occupational products, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative.Source →
  • USFDAinactive ingredient databaseRoute: TOPICAL; Dosage form: EMULSION; Potency: 0.08 %w/w
    • Route: TOPICAL; Dosage form: EMULSION; Potency: 0.08 %w/wSource →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Dimethoxane. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Dimethoxane yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2011-03-03

    Open →
  • EPA Chemical and Products Database

    exposure · updated January 7, 2008

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Dimethoxane in a product composition. These are source records, not Greenveil catalog products.

Source records

33

Named organisations

6

Raw materialsSpecialty occupational productsLaboratory suppliesVehicle

Typical roles

PreservativeAntimicrobial
See products using Dimethoxane →