Skip to content

GREENVEIL

  • beauty
  • industrial
  • pharma

Naphazoline

CAS 835-31-4 · 100/100 · High conf.

Also registered as 1 other CAS number

10061-11-7

Naphazoline chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Naphazoline in plain language

What it is

On cosmetic ingredient lists it appears as “Naphazoline hcl”.

Also known as Naphazoline hcl · Naphazoline (INN) and its salts · 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole · 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)- · 2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE · 2-(1-Naphthalenylmethyl)-2-imidazoline

Show all 23 names

2-Imidazoline, 2-(1-naphthylmethyl)- · AK Con · Antan · Antigaimorit · Ciba 2020/R · Clearine · Nafazolin · Naphazolin · Naphazolinum · Vasoconstrictor Pensa · R01AA08 · R01AB02 · S01GA01 · Tele Stulln · alpha-Naphthylmethyl imidazoline · nafazolina · naphthizinum (for the nitrate)

What it does

We don't have a plain-language description for Naphazoline yet.

Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Naphazoline (INN) and its salts is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial

  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 244.
    • Cosmetics Regulation annex II / ref 244.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 6 active drug products and 6 total products.
    • FDA NDC lists this ingredient in 6 active drug products and 6 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Naphazoline. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Naphazoline yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-20

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2020-08-31

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Naphazoline in a product composition. These are source records, not Greenveil catalog products.

Source records

6

See products using Naphazoline →

Catalog

Found in these products

Their ingredient lists include Naphazoline; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1 →Find products without it →