- beauty
- industrial
Musk ambrette
CAS 83-66-9 · 100/100 · High conf.
Concern score
Musk ambrette in plain language
Also known as 4-tert.-Butyl-3-methoxy-2,6-dinitrotoluene (Musk ambrette) · 6-TERT-BUTYL-3-METHYL-2,4-DINITROANISOLE · 1-tert-Butyl-2-methoxy-4-methyl-3,5-dinitrobenzene · Artificial musk ambrette · Musk ambrette (artificial) · Muskambrette
Show all 16 names
Synthetic musk ambrette · 1,1-dimethylethyl-2-methoxy-4-methyl-3-benzene · 1-(1,1-Dimethylethyl)-2-methoxy-4-methyl-3,5-dinitrobenzene · 2-methoxy-3,5-dinitro-4-methyl-t-butylbenzene · 4-tert-Butyl-2,6-dinitro-3-methoxytoluene · 4-tert-Butyl-3-methoxy-2,6-dinitrotoluene · Amber musk · Ambrette musk · Anisole, 6-tert-butyl-3-methyl-2,4-dinitro- · Musk ambrette--nlfg
Used in consumer products as a fragrance ingredient and a flavouring.
- Fragrance
- Flavouring
- Critical concern: no hazard classifications on record. It is banned in EU cosmetics.
Why it's flagged
4-tert.-Butyl-3-methoxy-2,6-dinitrotoluene (Musk ambrette) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.
RestrictedEU EC — banned
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
Restrictions first, then routine listings from published regulatory sources.
- EU Annex II — prohibited
- EU prohibited in cosmetics
- Found in consumer products
- Industrial
- View source →banned
EUEC
Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.
EUCosIngActiveCosmetics Regulation annex II / ref 414.
- Cosmetics Regulation annex II / ref 414.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Fragrance, Flavouring and nutrient.
- EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Fragrance, Flavouring and nutrient.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
No expert opinion on file for Musk ambrette. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for Musk ambrette yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2010-10-20
- Open →
EPA Chemical and Products Database
exposure · updated January 7, 2008
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Reference links (1)
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
Not a strong fit for fragrance avoidance because it carries Fragrance.
The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.
Where it has been recorded
How often EPA CPDat has listed Musk ambrette in a product composition. These are source records, not Greenveil catalog products.
Named organisations
5
Typical roles