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Musk ambrette

CAS 83-66-9 · 100/100 · High conf.

Musk ambrette chemical structure

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Musk ambrette in plain language

What it is

Also known as 4-tert.-Butyl-3-methoxy-2,6-dinitrotoluene (Musk ambrette) · 6-TERT-BUTYL-3-METHYL-2,4-DINITROANISOLE · 1-tert-Butyl-2-methoxy-4-methyl-3,5-dinitrobenzene · Artificial musk ambrette · Musk ambrette (artificial) · Muskambrette

Show all 16 names

Synthetic musk ambrette · 1,1-dimethylethyl-2-methoxy-4-methyl-3-benzene · 1-(1,1-Dimethylethyl)-2-methoxy-4-methyl-3,5-dinitrobenzene · 2-methoxy-3,5-dinitro-4-methyl-t-butylbenzene · 4-tert-Butyl-2,6-dinitro-3-methoxytoluene · 4-tert-Butyl-3-methoxy-2,6-dinitrotoluene · Amber musk · Ambrette musk · Anisole, 6-tert-butyl-3-methyl-2,4-dinitro- · Musk ambrette--nlfg

What it does

Used in consumer products as a fragrance ingredient and a flavouring.

  • Fragrance
  • Flavouring
Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

4-tert.-Butyl-3-methoxy-2,6-dinitrotoluene (Musk ambrette) is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 414.
    • Cosmetics Regulation annex II / ref 414.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Fragrance, Flavouring and nutrient.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Fragrance, Flavouring and nutrient.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Musk ambrette. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Musk ambrette yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-20

    Open →
  • EPA Chemical and Products Database

    exposure · updated January 7, 2008

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

books.google.com

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Musk ambrette in a product composition. These are source records, not Greenveil catalog products.

Named organisations

5

Typical roles

FragranceFlavouring
See products using Musk ambrette →