# alpha-Arbutin

URL: https://app.greenveil.ai/ingredients/ingredient_cas_84380_01_8
Categories: beauty, cleaning, pharma
Functions: Antioxidant, Bleaching agent, Softener and conditioner
Identifier: 84380-01-8

> alpha-Arbutin is used as antioxidant / bleaching agent. Greenveil chemical-concern score: 70/100 — High concern based on regulatory listings.. Assessed from 7 sources.

## Safety assessment

- Chemical concern score: 70/100 — High concern based on regulatory listings.
- Confidence: 4
- Rationale: 4-Hydroxyphenyl-alpha-D-glucopyranoside is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: restricted — Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: (a) Face cream (b) Body lotion Maximum concentration: (a) 2 % (b) 0,5 % Other conditions: Hydroquinone levels shall remain as low as possible in formulations containing alpha-Arbutin and shall not be higher than the unavoidable trace level. From 1 February 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not complying with the conditions…
- US: commercial use observed — EPA CPDat observed this chemical in 21 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Antioxidant, Softener and conditioner, Bleaching agent.
- US: marketed drug occurrence — FDA NDC lists this ingredient in 5 active drug products and 5 total products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

_Assessed by Greenveil._